Biotin Diacid

Base Information

Chemical Name:Biotin Diacid
CAS No.:57671-79-1
Molecular Formula:C11H16N2O5S
Molecular Weight:288.324
Hs Code.:
Mol file:57671-79-1.mol

Synonyms:Biotin Diacid;2-[3-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]iMidazol-4-yl]propyl]propanedioic Acid;Biotin IMpurity B

Suppliers and Price of Biotin Diacid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Biotin diacid
5mg
$ 807.00

Biosynth Carbosynth
Biotin diacid
1 mg
$ 250.00

AK Scientific
BiotinDiacid
5mg
$ 860.00

AK Scientific
BiotinDiacid
1mg
$ 387.00

Total 9 raw suppliers

Chemical Property of Biotin Diacid

Chemical Property:

PSA：144.52000
LogP:0.07630
Storage Temp.:Refrigerator
Solubility.:Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Biotin diacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Biotin Diacid (Biotin EP Impurity B) is an impurity of Biotin (B389040).

Technology Process of Biotin Diacid

There total 10 articles about Biotin Diacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59999-70-1
(3aR)-3c-bromo-(3ar,7ac)-hexahydro-thieno[3,2-b]pyridin-5-one

: 57671-79-1
[3-((3aS)-2-oxo-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-propyl]-malonic acid

Guidance literature:: Multi-step reaction with 6 steps

1: LiN₃ / dimethylformamide / 2.5 h / 130 °C

2: H₂ / Pd-C / ethanol / 16 h / 25 °C / 2327.2 Torr

3: (i) aq. Ba(OH)2, (ii) /BRN= 1098367/, (iii) /BRN= 1098229/, H₂SO₄

4: LiBH₄ / tetrahydrofuran / 3.5 h / Heating

5: HBr / acetic acid / 0.5 h / 100 °C

6: (i) Na, (ii) /BRN= 4047078/, (iii) aq. Ba(OH)2, MeOH

With lithium borohydride; lithium azide; hydrogen bromide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/ja00463a042

Reference yield:

: 57671-73-5
(3aS)-3t-azido-(3ar,7ac)-hexahydro-thieno[3,2-b]pyridin-5-one

: 57671-79-1
[3-((3aS)-2-oxo-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-propyl]-malonic acid

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd-C / ethanol / 16 h / 25 °C / 2327.2 Torr

2: (i) aq. Ba(OH)2, (ii) /BRN= 1098367/, (iii) /BRN= 1098229/, H₂SO₄

3: LiBH₄ / tetrahydrofuran / 3.5 h / Heating

4: HBr / acetic acid / 0.5 h / 100 °C

5: (i) Na, (ii) /BRN= 4047078/, (iii) aq. Ba(OH)2, MeOH

With lithium borohydride; hydrogen bromide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetic acid;
DOI:10.1021/ja00463a042

Reference yield:

: 57671-70-2
3-((2S)-4c-amino-3t-bromo-tetrahydro-thiophen-2r-yl)-propionic acid methyl ester; hydrobromide

: 57671-79-1
[3-((3aS)-2-oxo-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-propyl]-malonic acid

Guidance literature:: Multi-step reaction with 7 steps

1: NaOAc / acetic acid / 7 h / Heating

2: LiN₃ / dimethylformamide / 2.5 h / 130 °C

3: H₂ / Pd-C / ethanol / 16 h / 25 °C / 2327.2 Torr

4: (i) aq. Ba(OH)2, (ii) /BRN= 1098367/, (iii) /BRN= 1098229/, H₂SO₄

5: LiBH₄ / tetrahydrofuran / 3.5 h / Heating

6: HBr / acetic acid / 0.5 h / 100 °C

7: (i) Na, (ii) /BRN= 4047078/, (iii) aq. Ba(OH)2, MeOH

With lithium borohydride; lithium azide; hydrogen bromide; hydrogen; sodium acetate; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/ja00463a042