(5-Fluorobenzofuran-2-yl)boronic acid

Base Information

• Chemical Name: (5-Fluorobenzofuran-2-yl)boronic acid
• CAS No.: 473416-33-0
• Molecular Formula: C8H6BFO3
• Molecular Weight: 179.9408432
• Hs Code.: 2932990090
• Mol file: 473416-33-0.mol

Synonyms:(5-Fluorobenzofuran-2-yl)boronic acid;5-fluorobenzofuran-2-boronic acid

Chemical Property of (5-Fluorobenzofuran-2-yl)boronic acid

Chemical Property:

• Boiling Point: 343.8±45.0 °C(Predicted)
• PKA: 5.88±0.30(Predicted)
• PSA: 53.60000
• Density: 1.40±0.1 g/cm3(Predicted)
• LogP: 0.25170
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

(5-Fluoro-2-benzofuranyl)boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (5-Fluoro-2-benzofuranyl)boronic Acid serves as a reagent for the preparation of heterocyclic compounds for the inhibition of PASK useful for the treatment of diseases like diabetes mellitus.

Technology Process of (5-Fluorobenzofuran-2-yl)boronic acid

There total 5 articles about (5-Fluorobenzofuran-2-yl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

5-Fluoro[b]benzofuran (24410-59-1) + Triisopropyl borate (5419-55-6) → (5-fluorobenzofuran-2-yl)boronic acid (473416-33-0)

Guidance literature:

5-Fluoro[b]benzofuran; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -60 - -10 ℃; for 75h; Inert atmosphere;

Triisopropyl borate; In tetrahydrofuran; hexane; at -60 - 20 ℃; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; hexane;

Reference yield:

5-Fluoro[b]benzofuran (24410-59-1) + triethyl borate (150-46-9) → (5-fluorobenzofuran-2-yl)boronic acid (473416-33-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 3.33333h;

Reference yield:

5-Fluoro[b]benzofuran (24410-59-1) + Triisopropyl borate (5419-55-6) + water (7732-18-5) → (5-fluorobenzofuran-2-yl)boronic acid (473416-33-0)

Guidance literature:

5-Fluoro[b]benzofuran; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -60 - -10 ℃; for 1.25h; Inert atmosphere;

Triisopropyl borate; In tetrahydrofuran; hexane; at -60 - 20 ℃;

water; With hydrogenchloride; In tetrahydrofuran; hexane; at 20 ℃; for 1h;

upstream raw materials:

5-Fluoro[b]benzofuran

triethyl borate

2-(4-Fluorophenoxy)-acetaldehyde Diethyl Acetal

4-Fluorophenol