1-(3-((((2S,3S,4R,5R)-5-(6-aMino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl)(isopropyl)aMino)propyl)-3-(4-(tert-butyl)phenyl)urea

Base Information

Chemical Name:1-(3-((((2S,3S,4R,5R)-5-(6-aMino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl)(isopropyl)aMino)propyl)-3-(4-(tert-butyl)phenyl)urea
CAS No.:1381761-52-9
Molecular Formula:C27H40N8O4
Molecular Weight:540.666
Hs Code.:
Mol file:1381761-52-9.mol

Synonyms:1-(3-((((2S,3S,4R,5R)-5-(6-aMino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl)(isopropyl)aMino)propyl)-3-(4-(tert-butyl)phenyl)urea

Suppliers and Price of 1-(3-((((2S,3S,4R,5R)-5-(6-aMino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl)(isopropyl)aMino)propyl)-3-(4-(tert-butyl)phenyl)urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3-((((2S,3S,4R,5R)-5-(6-aMino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl)(isopropyl)aMino)propyl)-3-(4-(tert-butyl)phenyl)urea

Chemical Property:

PSA：163.68000
LogP:3.29250

Purity/Quality:: 98%,99%, ^*data from raw suppliers

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Pictogram(s):
Hazard Codes:

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Technology Process of 1-(3-((((2S,3S,4R,5R)-5-(6-aMino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl)(isopropyl)aMino)propyl)-3-(4-(tert-butyl)phenyl)urea

There total 21 articles about 1-(3-((((2S,3S,4R,5R)-5-(6-aMino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl)(isopropyl)aMino)propyl)-3-(4-(tert-butyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1381761-51-8
C₃₀H₄₄N₈O₄

: 1381761-52-9
1-(3-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tertbutyl)phenyl)urea

Guidance literature:: C₃₀H₄₄N₈O₄; With water; trifluoroacetic acid; at 20 ℃; for 1.5h;

In methanol; at 20 ℃; for 1h;

Reference yield: 80.0%

: 1381761-53-0
1-(4-(tert-butyl)phenyl)-3-(3-oxopropyl)urea

: C₁₃H₂₀N₆O₃

: 1381761-52-9
1-(3-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tertbutyl)phenyl)urea

Guidance literature:: 1-(4-(tert-butyl)phenyl)-3-(3-oxopropyl)urea; C₁₃H₂₀N₆O₃; With acetic acid; In acetonitrile; at 50 ℃; for 0.166667h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In acetonitrile; at 50 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2017.12.064

Reference yield:

: 21950-36-7
5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine

: 1381761-52-9
1-(3-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tertbutyl)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

2.1: acetic acid / tetrahydrofuran; methanol / 6 h / 20 °C / 4 A Molecular sieve

2.2: 20 °C

3.1: trifluoroacetic acid; water / 1.5 h / 20 °C

3.2: basic resin / 1 h / 20 °C

With water; sodium tris(acetoxy)borohydride; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;