3-Methoxyestra-1,3,5(10),15-tetrene-17-one

Base Information

• Chemical Name: 3-Methoxyestra-1,3,5(10),15-tetrene-17-one
• CAS No.: 17748-68-4
• Molecular Formula: C19H22O2
• Molecular Weight: 282.382
• Mol file: 17748-68-4.mol

Synonyms:3-Methoxy-1,3,5(10),15-estratetren-17-one;3-Methoxyestra-1,3,5(10),15-tetrene-17-one

Chemical Property of 3-Methoxyestra-1,3,5(10),15-tetrene-17-one

Chemical Property:

• PSA: 26.30000
• LogP: 3.89640

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methoxyestra-1,3,5(10),15-tetrene-17-one

There total 20 articles about 3-Methoxyestra-1,3,5(10),15-tetrene-17-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(17β)-3-methoxyestra-1,3,5(10),15-tetraen-17-ol (17980-88-0) → 3-methoxy-estra-1,3,5(10),15-tetraen-17-one (17748-68-4)

Guidance literature:

With oxalyl dichloride; C₆F₁₃-(CH₂)2-S(O)-CH₃; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/ja016057i

Reference yield: 80.0%

(13S,17S)-3-Methoxy-13-methyl-7,8,9,11,12,13,14,17-octahydro-6H-cyclopenta[a]phenanthren-17-ol (17980-88-0,59126-64-6) → 15-Dehydrooestron-methylaether (17550-10-6,17748-68-4)

Guidance literature:

With oxalyl dichloride; C₄F₉CH₂CH₂S(O)CH₃; In dichloromethane; at -30 ℃;

DOI:10.1016/S0040-4020(02)00207-7

Reference yield: 64.0%

estrone 3-methyl ether (1624-62-0) → 3-methoxy-estra-1,3,5(10),15-tetraen-17-one (17748-68-4)

Guidance literature:

estrone 3-methyl ether; With bis(2,2,6,6-tetramethyl-1-piperidyl)zinc; In toluene; at 0 ℃; for 0.166667h; Inert atmosphere;

With bis(η3-allyl-μ-chloropalladium(II)); allyl diethyl phosphate; In toluene; at 0 - 120 ℃; for 2h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.7b03818

upstream raw materials:

(13S,17S)-3-Methoxy-13-methyl-7,8,9,11,12,13,14,17-octahydro-6H-cyclopenta[a]phenanthren-17-ol

p-toluenesulfonic acid monohydrate

17,17-ethanediyldioxy-3-methoxy-estra-1,3,5⁽¹⁰⁾,15-tetraene

acetone

Downstream raw materials:

3-methoxy-14β-estra-1,3,5(10),15-tetraen-17-one

14-dehydroestrone 3-methyl ether

estrone 3-methyl ether

(17β)-3-methoxyestra-1,3,5(10),15-tetraen-17-ol