N-(piperidin-2-ylmethyl)benzamide

Base Information

• Chemical Name: N-(piperidin-2-ylmethyl)benzamide
• CAS No.: 127722-73-0
• Molecular Formula: C13H18N2O
• Molecular Weight: 218.299
• European Community (EC) Number: 965-053-2
• Mol file: 127722-73-0.mol

Synonyms:N-(piperidin-2-ylmethyl)benzamide;127722-73-0;N-[(piperidin-2-yl)methyl]benzamide;SCHEMBL3760743;CFA72273;AKOS000149990;AKOS022478001;CS-0253392;EN300-64175;G57378;Z234895871

Chemical Property of N-(piperidin-2-ylmethyl)benzamide

Chemical Property:

• PSA: 41.13000
• LogP: 2.27820
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 218.141913202
• Heavy Atom Count: 16
• Complexity: 224

Purity/Quality:

99% ^*data from raw suppliers

N-(piperidin-2-ylmethyl)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNC(C1)CNC(=O)C2=CC=CC=C2

Technology Process of N-(piperidin-2-ylmethyl)benzamide

There total 5 articles about N-(piperidin-2-ylmethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

N-((pyridin-2-yl)methyl)benzamide (35854-47-8) → N-<((2-piperidinyl)methyl)>benzamide (127722-73-0)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid; Ambient temperature;

DOI:10.1016/0223-5234(90)90159-Z

Reference yield: 10.0%

C-piperidin-2-yl-methylamine (22990-77-8,111478-74-1,111478-77-4) + benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) → N-<((2-piperidinyl)methyl)>benzamide (127722-73-0)

Guidance literature:

With bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct; In tetrahydrofuran; at 130 ℃; for 0.133333h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.tet.2013.08.062

Reference yield:

2-(Aminomethyl)pyridine (3731-51-9) → N-<((2-piperidinyl)methyl)>benzamide (127722-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / triethylamine / 1,2-dichloro-ethane / 3 h / 60 °C

2: 64 percent / H₂ / PtO₂ / acetic acid / Ambient temperature

With hydrogen; triethylamine; platinum(IV) oxide; In acetic acid; 1,2-dichloro-ethane;

DOI:10.1016/0223-5234(90)90159-Z

upstream raw materials:

N-((pyridin-2-yl)methyl)benzamide

2-(Aminomethyl)pyridine

benzoyl chloride

C-piperidin-2-yl-methylamine