N-Methyl-2,3,4,9-tetrahydrothiopyrano(2,3-b)indole-4-methylamine hydrochloride

Base Information

Chemical Name:N-Methyl-2,3,4,9-tetrahydrothiopyrano(2,3-b)indole-4-methylamine hydrochloride
CAS No.:73425-60-2
Molecular Formula:C₁₃H₁₆N₂S*ClH
Molecular Weight:268.81
Hs Code.:
DSSTox Substance ID:DTXSID30994160

Synonyms:N-Methyl-2,3,4,9-tetrahydrothiopyrano(2,3-b)indole-4-methylamine hydrochloride;4-((Methylamino)methyl)-2,3,4,9-tetrahydrothiopyrano(2,3-b)indole hydrochloride;Thiopyrano(2,3-b)indole, 2,3,4,9-tetrahydro-4-((methylamino)methyl)-, monohydrochloride;Thiopyrano(2,3-b)indole-4-methylamine, 2,3,4,9-tetrahydro-N-methyl-, hydrochloride;73425-60-2;DTXSID30994160;LS-153300;N-Methyl-1-(2,3,4,9-tetrahydrothiopyrano[2,3-b]indol-4-yl)methanamine--hydrogen chloride (1/1)

Suppliers and Price of N-Methyl-2,3,4,9-tetrahydrothiopyrano(2,3-b)indole-4-methylamine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of N-Methyl-2,3,4,9-tetrahydrothiopyrano(2,3-b)indole-4-methylamine hydrochloride

Chemical Property:

Vapor Pressure:1.17E-06mmHg at 25°C
Boiling Point:401.6°Cat760mmHg
Flash Point:196.7°C
Density:g/cm³
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:268.0800974
Heavy Atom Count:17
Complexity:246

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNCC1CCSC2=C1C3=CC=CC=C3N2.Cl

Technology Process of N-Methyl-2,3,4,9-tetrahydrothiopyrano(2,3-b)indole-4-methylamine hydrochloride

There total 9 articles about N-Methyl-2,3,4,9-tetrahydrothiopyrano(2,3-b)indole-4-methylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 496-30-0
indolin-2-thione

: 73425-60-2,130222-43-4
4-methylaminomethyl-2,3,4,9-tetrahydrothiopyrano<2,3-b>indole hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: K₂CO₃ / acetone / 4 h / 23 °C

2: 3M HCl / methanol / 0.25 h / 23 °C

3: 81 percent / DMAP, Et₃N / CH₂Cl₂ / 3 h / -13 °C

4: 86 percent / PPh₃, diethyl azodicarboxylate / tetrahydrofuran / 1) -13 deg C, 1 h 2) 3 deg C, 30 min

5: LiAlH₄ / diethyl ether / 0.5 h / -65 °C

8: LiAlH₄ / diethyl ether / 25 °C

With hydrogenchloride; dmap; lithium aluminium tetrahydride; potassium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone;
DOI:10.1039/P19900000827

Reference yield:

: 130202-53-8
2-[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethylsulfanyl]-1H-indole

: 73425-60-2,130222-43-4
4-methylaminomethyl-2,3,4,9-tetrahydrothiopyrano<2,3-b>indole hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: 3M HCl / methanol / 0.25 h / 23 °C

2: 81 percent / DMAP, Et₃N / CH₂Cl₂ / 3 h / -13 °C

3: 86 percent / PPh₃, diethyl azodicarboxylate / tetrahydrofuran / 1) -13 deg C, 1 h 2) 3 deg C, 30 min

4: LiAlH₄ / diethyl ether / 0.5 h / -65 °C

7: LiAlH₄ / diethyl ether / 25 °C

With hydrogenchloride; dmap; lithium aluminium tetrahydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1039/P19900000827

Reference yield:

: 2-Acetoxy-benzoic acid (R)-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-(1H-indol-2-ylsulfanyl)-propyl ester

: 73425-60-2,130222-43-4
4-methylaminomethyl-2,3,4,9-tetrahydrothiopyrano<2,3-b>indole hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: LiAlH₄ / diethyl ether / 0.5 h / -65 °C

4: LiAlH₄ / diethyl ether / 25 °C

With lithium aluminium tetrahydride; In diethyl ether;
DOI:10.1039/P19900000827