(2S)-2-(2-methylphenyl)piperidine

Base Information

Chemical Name:(2S)-2-(2-methylphenyl)piperidine
CAS No.:1228547-99-6
Molecular Formula:C12H17N
Molecular Weight:175.27
Hs Code.:
DSSTox Substance ID:DTXSID701300448
Mol file:1228547-99-6.mol

Synonyms:(2S)-2-(2-methylphenyl)piperidine;(S)-2-(o-tolyl)piperidine;1228547-99-6;(S)-2-O-TOLYLPIPERIDINE;SCHEMBL17304029;DTXSID701300448;AM9022;Y13692

Suppliers and Price of (2S)-2-(2-methylphenyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of (2S)-2-(2-methylphenyl)piperidine

Chemical Property:

PSA：12.03000
LogP:3.13840
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:175.136099547
Heavy Atom Count:13
Complexity:155

Purity/Quality:: 99.00% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=CC=C1C2CCCCN2
Isomeric SMILES:CC1=CC=CC=C1[C@@H]2CCCCN2

Technology Process of (2S)-2-(2-methylphenyl)piperidine

There total 6 articles about (2S)-2-(2-methylphenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 105902-01-0
6-o-tolyl-2,3,4,5-tetrahydro-pyridine

: 118576-99-1,1228547-99-6
2-(2'-methylphenyl)piperidine

Guidance literature:: With diethoxymethylane; diethylzinc; ((2S,2'S)-((2-hydroxy-5-methyl-1,3-phenylene)bis(methylene))bis(pyrrolidine-1,2-diyl))bis(diphenylmethanol); In tetrahydrofuran; toluene; at 4 ℃; for 48h; Inert atmosphere;
DOI:10.1002/adsc.202001043

Reference yield: 50.0%

: 110-89-4
piperidine

: 95-46-5
2-methylphenyl bromide

: 118576-99-1,1228547-99-6
2-(2'-methylphenyl)piperidine

Guidance literature:: piperidine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.0833333h; Inert atmosphere;

With 2,2,2-Trifluoroacetophenone; In diethyl ether; hexane; at -78 ℃; for 0.166667h; Inert atmosphere;

2-methylphenyl bromide; With n-butyllithium; In diethyl ether; hexane; at -78 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1002/anie.202011641

Reference yield:

: 932-31-0
ortho-tolylmagnesium bromide

: 1228547-99-6
(R)-2-o-Tolyl-piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / tetrahydrofuran / 12 h / -78 °C

2: H₂ / Pd/C

With hydrogen; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/jo980719d