Quetiapine Dimer Impurity

Base Information

• Chemical Name: Quetiapine Dimer Impurity
• CAS No.: 945668-94-0
• Molecular Formula: C30H24N4S2
• Molecular Weight: 504.679
• Mol file: 945668-94-0.mol

Synonyms:Quetiapine Dimer Impurity;11,11'-(1,4-Piperazinediyl)bis-dibenzo[b,f][1,4]thiazepine;Quetiapine DiMer;Quetiapine IMpurity D/Quetiapine DiMer IMpurity;Quetiapine EP Impurity D

Chemical Property of Quetiapine Dimer Impurity

Chemical Property:

• Melting Point: 291-294°C
• Boiling Point: 684.7±65.0 °C(Predicted)
• PKA: 5.03±0.70(Predicted)
• PSA: 81.80000
• Density: 1.34±0.1 g/cm3(Predicted)
• LogP: 5.83720
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%min. ^*data from raw suppliers

Quetiapine dimer impurity ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Quetiapine Dimer Impurity (Quetiapine EP Impurity D) is an impurity of Quetiapine.

Technology Process of Quetiapine Dimer Impurity

There total 1 articles about Quetiapine Dimer Impurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazine (110-85-0) + 11-chloro-dibenzo[b,f][1,4]thiazepine (13745-86-3) → 11-(1-piperazinyl)dibenzo[b,f][1,4]thiazepine (5747-48-8) + 11-[4-(2-hydroxyethyl)-1-piperazinyl]dibenzo[b,f][1,4]thiazepine (945668-94-0)

Guidance literature:

at 100 ℃; for 1 - 2h;

upstream raw materials:

piperazine

11-chloro-dibenzo[b,f][1,4]thiazepine

Refernces