2-BroMo-3-(difluoroMethyl)pyridine, 97%

Base Information

• Chemical Name: 2-BroMo-3-(difluoroMethyl)pyridine, 97%
• CAS No.: 1211515-00-2
• Molecular Formula: C₆H₄BrF₂N
• Molecular Weight: 208.005
• Hs Code.: 2933399090
• Mol file: 1211515-00-2.mol

Synonyms:2-BroMo-3-(difluoroMethyl)pyridine, 97%

Chemical Property of 2-BroMo-3-(difluoroMethyl)pyridine, 97%

Chemical Property:

• Refractive Index: n20/D1.522
• Flash Point: 107℃
• PSA: 12.89000
• Density: 1.704 at 25 °C
• LogP: 2.78170
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-3-(difluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BroMo-3-(difluoroMethyl)pyridine, 97%

There total 1 articles about 2-BroMo-3-(difluoroMethyl)pyridine, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromopyridine-3-carboxaldehyde (128071-75-0) → 2-bromo-3-(difluoromethyl)pyridine (1211515-00-2)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at 25 ℃; for 4h;

DOI:10.1016/j.jfluchem.2019.05.006

Reference yield: 25.0%

2-bromo-3-(difluoromethyl)pyridine (1211515-00-2) + (4-{2-[(S)-amino-(4,4-difluorocyclohexyl)methyl]-4-fluoro-1-(2-trimethylsilylethoxymethyl)benzimidazol-5-yl}tetrahydropyran-4-yl)-(3,3-difluoroazetidin-1-yl)methanone → (3,3-difluoroazetidin-1-yl)-(4-{2-[(S)-(4,4-difluorocyclohexyl)-{[3-(difluoromethyl)pyridin-2-yl]amino}methyl]-4-fluoro-1H-benzimidazol-5-yl}tetrahydropyran-4-yl)methanone

Guidance literature:

2-bromo-3-(difluoromethyl)pyridine; (4-{2-[(S)-amino-(4,4-difluorocyclohexyl)methyl]-4-fluoro-1-(2-trimethylsilylethoxymethyl)benzimidazol-5-yl}tetrahydropyran-4-yl)-(3,3-difluoroazetidin-1-yl)methanone; With 2-[(tert-butyl)phenylphosphino]-2',6'-bis(N,N-dimethylamino)biphenyl Pd G₃ precatalyst; sodium t-butanolate; In 1,4-dioxane; at 75 ℃; for 72h; Inert atmosphere;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

2-bromo-3-(difluoromethyl)pyridine (1211515-00-2) + (2-(5-(2,4-dimethyloxazole-5-carboxamido)-2-fluorophenyl)-[1,2,4]-triazolo[1,5-a]pyrimidin-6-yl)boronic acid → N-(3-(6-(3-(difluoromethyl)pyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-4-fluorophenyl)-2,4-dimethyloxazole-5-carboxamide

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c00499

upstream raw materials:

2-bromopyridine-3-carboxaldehyde

Refernces

• 1、 -. "SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME". Page/Page column 144; 422. . Retrieved 2021/11/20.