7-Methoxy-2,3-dihydro-1H-inden-1-amine

Base Information

• Chemical Name: 7-Methoxy-2,3-dihydro-1H-inden-1-amine
• CAS No.: 1032279-33-6
• Molecular Formula: C10H13NO
• Molecular Weight: 163.21632
• Hs Code.: 2922199090
• DSSTox Substance ID: DTXSID70595190
• Mol file: 1032279-33-6.mol

Synonyms:7-Methoxy-2,3-dihydro-1H-inden-1-amine;1032279-33-6;7-Methoxy-2,3-dihydro-1H-inden-1-amine HCl;rac-7-methoxy-indane-1-ylamine;7-methoxy-indan-1-ylamine;7-methoxy-indane-1-ylamine;SCHEMBL265887;(R)-7-Methoxyindane-1-amine;rac-7-methoxy-indan-1-ylamine;DTXSID70595190;RWAJCHDFYSLZND-UHFFFAOYSA-N;MFCD09256288;MFCD15527075;AKOS016003136;DS-3683;SB76156;SY326484;DB-296801;CS-0303255;N11280;EN300-3002799;A853016

Chemical Property of 7-Methoxy-2,3-dihydro-1H-inden-1-amine

Chemical Property:

• PSA: 35.25000
• LogP: 2.34150
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 163.099714038
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

97% ^*data from raw suppliers

7-Methoxy-2,3-dihydro-1H-inden-1-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1C(CC2)N

Technology Process of 7-Methoxy-2,3-dihydro-1H-inden-1-amine

There total 5 articles about 7-Methoxy-2,3-dihydro-1H-inden-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

7-methoxy-indan-1-one oxime (908108-58-7) → 1-amino-7-methoxyindane (1032279-33-6)

Guidance literature:

With hydrogen; Raney-Nickel; In tetrahydrofuran; methanol; at 60 ℃; for 22h; under 75007.5 Torr;

Reference yield:

1-amino-7-methoxyindane hydrochloride (1187160-18-4) → 1-amino-7-methoxyindane (1032279-33-6)

Guidance literature:

With sodium hydroxide; In methanol; at 0 - 25 ℃; for 3h;

DOI:10.1002/ardp.201400257

Reference yield:

1-azido-4-bromo-7-methoxyindane → 1-amino-7-methoxyindane (1032279-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: chloroform; palladium on activated charcoal; hydrogen / methanol / 20 h / 25 °C / Inert atmosphere

2: sodium hydroxide / methanol / 3 h / 0 - 25 °C

With chloroform; palladium on activated charcoal; hydrogen; sodium hydroxide; In methanol;

DOI:10.1002/ardp.201400257

upstream raw materials:

7-methoxy-indan-1-one oxime

1-amino-7-methoxyindane hydrochloride

4-bromo-7-methoxy-2,3-dihydro-1H-inden-1-ol