ent-Calindol Amide

Base Information

• Chemical Name: ent-Calindol Amide
• CAS No.: 1217835-51-2
• Molecular Formula: C₂₁H₁₈N₂O
• Molecular Weight: 314.387
• Mol file: 1217835-51-2.mol

Synonyms:ent-Calindol Amide;(S)-N-[1-(1-Naphthyl)ethyl]indole-2-carboxaMide;N-[(1S)-1-(1-Naphthalenyl)ethyl]-1H-Indole-2-carboxaMide

Chemical Property of ent-Calindol Amide

Chemical Property:

• Boiling Point: 620.2±38.0 °C(Predicted)
• PKA: 14.86±0.46(Predicted)
• PSA: 48.38000
• Density: 1.236±0.06 g/cm3(Predicted)
• LogP: 5.38690
• Solubility.: Chloroform, Dichloromethane, Dimethylformamide, Methanol,

Purity/Quality:

ent-CalindolAmide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of ent-Calindol

Technology Process of ent-Calindol Amide

There total 3 articles about ent-Calindol Amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Indole-2-carboxylic acid (1477-50-5,1228050-17-6) + (R)-1-(1-Naphthyl)ethylamine (3886-70-2) → (R)-N-[1-(1-naphthyl)ethyl]indole-2-carboxamide (374933-28-5,1217835-51-2)

Guidance literature:

With thionyl chloride; triethylamine; In chloroform; N,N-dimethyl-formamide;

Reference yield:

Indole-2-carboxylic acid (1477-50-5,1228050-17-6) → (R)-N-[1-(1-naphthyl)ethyl]indole-2-carboxamide (374933-28-5,1217835-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / CHCl₃

2: triethylamine / CHCl₃

With thionyl chloride; triethylamine; In chloroform;

DOI:10.1016/j.bmcl.2004.03.056

Reference yield:

Indole-2-carbonyl chloride (58881-45-1) + (R)-1-(1-Naphthyl)ethylamine (3886-70-2) → (R)-N-[1-(1-naphthyl)ethyl]indole-2-carboxamide (374933-28-5,1217835-51-2)

Guidance literature:

With triethylamine; In chloroform;

DOI:10.1016/j.bmcl.2004.03.056

upstream raw materials:

Indole-2-carbonyl chloride

(R)-1-(1-Naphthyl)ethylamine

Indole-2-carboxylic acid