C-DIM12

Base Information

• Chemical Name: C-DIM12
• CAS No.: 178946-89-9
• Molecular Formula: C23H17ClN2
• Molecular Weight: 356.854
• Mol file: 178946-89-9.mol

Synonyms:C-DIM12;C-DIM12(1,1-bis (3'-indolyl)-1-(p-chlorophenyl) methane);C-DIMI2;3,3'-[(4-chlorophenyl)methylene]bis-1H-Indole

Chemical Property of C-DIM12

Chemical Property:

• Melting Point: 76-77 °C
• Boiling Point: 585.6±45.0 °C(Predicted)
• PKA: 16.40±0.30(Predicted)
• PSA: 31.58000
• Density: 1.324±0.06 g/cm3(Predicted)
• LogP: 6.48280
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml)

Purity/Quality:

99%, ^*data from raw suppliers

C-DIM12 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: C-DIM12 is a para-phenyl-substituted diindolylmethane (C-DIM) that is an orally bioavailable activator of nuclear receptor-related protein 1 (Nurr1/NR4A2). It is selective for Nurr1, not activating Nur77, neuron-derived orphan receptor 1 (Nor1), or the retinoid X receptor (RXR) in parallel luciferase assays. C-DIM12 (2.5-10 μM) inhibits proliferation of Ku7 and 253J B-V bladder cancer cells in a dose-dependent manner and induces apoptosis of KU7 cells in a Nurr1-dependent manner. In an orthotopic nude mouse model, C-DIM12 suppresses bladder cancer cell growth by 44 and 59% at doses of 12.5 and 25 mg/kg, respectively. C-DIM12 has neuroprotective properties, preventing dopaminergic cell loss and reducing the expression of NF-κB in the substantia nigra pars compacta in an MPTP mouse model of Parkinson’s disease. It also has analgesic and anti-inflammatory activity in the tail immersion and carrageenan paw edema assays at a dose of 100 mg/kg, without causing ulcers in rats.

Technology Process of C-DIM12

There total 38 articles about C-DIM12 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

indole (120-72-9) + 4-chlorobenzaldehyde (104-88-1) → bis(3-indolyl)-4-chlorophenylmethane (178946-89-9)

Guidance literature:

With 4,4'-(propane-1,3-diyl)bis(1-methyl-1,4-diazabicyclo-[2.2.2]octane-1,4-diium) tetra-hydrogensulfate; In water; at 20 ℃; for 2h; Green chemistry;

DOI:10.1039/c5ra01422k

Reference yield: 100.0%

indole (120-72-9) + (E)-4-chloro-N-(4-chlorobenzylidene)benzenamine (1751-80-0) → bis(3-indolyl)-4-chlorophenylmethane (178946-89-9)

Guidance literature:

With Montmorillonite K₁₀; In dichloromethane; at 0 ℃; for 12h;

DOI:10.1515/HC.2005.11.5.427

Reference yield: 98.0%

indole (120-72-9) + N-(4-chlorobenzylidene)aniline (2362-79-0) → bis(3-indolyl)-4-chlorophenylmethane (178946-89-9)

Guidance literature:

With zinc perchlorate; 1,3-bis[5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-ylmethyleneamino]thiourea; In dichloromethane; at 20 ℃; for 10h;

DOI:10.1016/j.cclet.2013.09.010

upstream raw materials:

indole

4-chlorobenzaldehyde

(E)-1-(4-chlorophenyl)-N-phenylmethanimine

(E)-4-chloro-N-(4-chlorobenzylidene)benzenamine

Downstream raw materials:

indole

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 178946-89-9 C-DIM12

Send

Send

Metric Ton KG G Pound L ML

Send

Send