Ethanone, 1-(2-amino-3-fluorophenyl)- (9CI)

Base Information

• Chemical Name: Ethanone, 1-(2-amino-3-fluorophenyl)- (9CI)
• CAS No.: 124623-26-3
• Molecular Formula: C8H8FNO
• Molecular Weight: 153.156
• Hs Code.: 2921420090
• Mol file: 124623-26-3.mol

Synonyms:Ethanone, 1-(2-amino-3-fluorophenyl)- (9CI);1-(2-Amino-3-fluorophenyl)ethanone

Chemical Property of Ethanone, 1-(2-amino-3-fluorophenyl)- (9CI)

Chemical Property:

• Boiling Point: 244.8±20.0 °C(Predicted)
• PKA: 0.91±0.10(Predicted)
• PSA: 43.09000
• Density: 1.201±0.06 g/cm3(Predicted)
• LogP: 2.19170

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

1-(2-Amino-3-fluorophenyl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(2-amino-3-fluorophenyl)- (9CI)

There total 8 articles about Ethanone, 1-(2-amino-3-fluorophenyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(3-fluoro-2-nitrophenyl)ethan-1-one (1214346-37-8) → 1-(2-amino-3-fluorophenyl)ethanone (124623-26-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 8h; under 760.051 Torr; Inert atmosphere;

Reference yield: 60.0%

N-(2-acetyl-6-fluorophenyl)-2,2,2-trifluoroacetamide (935292-90-3) → 1-(2-amino-3-fluorophenyl)ethanone (124623-26-3)

Guidance literature:

With methanol; sodium hydroxide; at 20 - 80 ℃; for 75h;

Reference yield:

2-Fluoroaniline (348-54-9) → 1-(2-amino-3-fluorophenyl)ethanone (124623-26-3)

Guidance literature:

In acetonitrile;

upstream raw materials:

2-Fluoroaniline

N-(2-acetyl-6-fluorophenyl)-2,2,2-trifluoroacetamide

3-fluoro-2-nitro-benzoic acid

3-fluoro-2-nitrobenzoylchloride

Downstream raw materials:

1-(2-amino-3-fluoro-5-iodophenyl)ethanone

C₁₀H₇Cl₃FNO₂