CPI 360

Base Information

• Chemical Name: CPI 360
• CAS No.: 1802175-06-9
• Molecular Formula: C25H31N3O4
• Molecular Weight: 437.53
• Mol file: 1802175-06-9.mol

Synonyms:CPI 360;CPI360;CPI-360

Chemical Property of CPI 360

Chemical Property:

• Boiling Point: 712.2±60.0 °C(Predicted)
• PKA: 11.01±0.10(Predicted)
• PSA: 85.35000
• Density: 1.26±0.1 g/cm3(Predicted)
• LogP: 4.26350

Purity/Quality:

99%, ^*data from raw suppliers

CPI-360(R) >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: CPI-360 is a selective EZH2 inhibitor with IC50 values of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2, respectively. It decreases cellular levels of H3K27me3 and H3K27me2 (EC50s = 56 and 65 nM, respectively), triggering cell cycle arrest and ultimately resulting in apoptosis in a large panel of non-Hodgkin’s lymphoma (NHL) cell lines. Twice daily, subcutaneous administration of 200 mg/kg of CPI-360 reduced tumor growth of KARPAS-422 xenografts in mice.

Technology Process of CPI 360

There total 55 articles about CPI 360 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methanaminium chloride + (R)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxylic acid → (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide (1802175-06-9)

Guidance literature:

With 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2015.06.056

Reference yield:

3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde (50675-18-8) → N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide (1450654-49-5,1802175-06-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: tetrahydrofuran; diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 4.25 h / 0 - 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 12 h / 70 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C / 760.05 Torr

5.1: acetic acid / ethanol / 12 h / 85 °C

6.1: sodium methylate / 1,4-dioxane / 0.25 h / Inert atmosphere

6.2: 12.25 h / 100 °C / Inert atmosphere

7.1: ethanol; sodium hydroxide / 4 h / Reflux

8.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 16.25 h / 0 - 20 °C

With sodium azide; ethanol; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium methylate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde (50675-18-8) → (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide (1802175-06-9) + (S)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide (1802175-06-9)

Guidance literature:

Multi-step reaction with 9 steps

1.1: tetrahydrofuran; diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 4.25 h / 0 - 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 12 h / 70 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C / 760.05 Torr

5.1: acetic acid / ethanol / 12 h / 85 °C

6.1: sodium methylate / 1,4-dioxane / 0.25 h / Inert atmosphere

6.2: 12.25 h / 100 °C / Inert atmosphere

7.1: ethanol; sodium hydroxide / 4 h / Reflux

8.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 16.25 h / 0 - 20 °C

9.1: Chiralpak IA column / methanol; dichloromethane; hexane; diethylamine / Resolution of racemate

With sodium azide; ethanol; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium methylate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; hexane; dichloromethane; dimethyl sulfoxide; diethylamine; N,N-dimethyl-formamide;

upstream raw materials:

3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

1-(tetrahydro-2H-pyran-4-yl)ethan-1-ol

1-(tetrahydro-2H-pyran-4-yl)ethyl methanesulfonate

4-(1-azidoethyl)tetrahydro-2H-pyran

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1802175-06-9 CPI 360

Send

Send

Metric Ton KG G Pound L ML

Send

Send