Norgnoscopine

Base Information

Chemical Name:Norgnoscopine
CAS No.:36017-64-8
Molecular Formula:C₂₁H₂₁NO₇
Molecular Weight:399.4
Hs Code.:
ChEMBL ID:CHEMBL3597096
DSSTox Substance ID:DTXSID90577352
Wikidata:Q82467315
Mol file:36017-64-8.mol

Synonyms:Norgnoscopine;36017-64-8;(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one;92621-03-9;CHEMBL3597096;DTXSID90577352;(3S)-6,7-Dimethoxy-3-(4-methoxy-5,6,7,8-tetrahydro-2H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one

Suppliers and Price of Norgnoscopine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Norgnoscopine

Chemical Property:

Boiling Point:583.8±50.0 °C(Predicted)
PKA:7.08±0.40(Predicted)
PSA：84.48000
Density:1.352±0.06 g/cm3(Predicted)
LogP:2.86840
Storage Temp.:-20°C Freezer, Under Inert Atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:399.13180201
Heavy Atom Count:29
Complexity:618

Purity/Quality:: 90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C2=C(C=C1)C(OC2=O)C3C4=C(C5=C(C=C4CCN3)OCO5)OC)OC
Isomeric SMILES:COC1=C(C2=C(C=C1)[C@H](OC2=O)[C@H]3C4=C(C5=C(C=C4CCN3)OCO5)OC)OC
Uses A benzylisoquinoline alkaloid.

Technology Process of Norgnoscopine

There total 28 articles about Norgnoscopine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 54383-36-7,1850-90-4
α-narcotine N-oxide

: 92621-03-9,36017-64-8
(3S)-6,7-dimethoxy-3-((R)-4-methoxy-5,6,7,8-tetrahydro-[1,3]dioxolo [4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one

Guidance literature:: With ferrous(II) sulfate heptahydrate; In methanol; at -5 ℃; for 8h;
DOI:10.1002/cmdc.201300395

Reference yield: 76.0%

: methyl 6-(3-(6-(2-((tert-butoxycarbonyl)amino)ethyl)-4-methoxybenzo[d][1,3]dioxol-5-yl)oxiran-2-yl)-2,3-dimethoxybenzoate

: 36017-64-8
(±)-β-N-demethyl noscapine

Guidance literature:: methyl 6-(3-(6-(2-((tert-butoxycarbonyl)amino)ethyl)-4-methoxybenzo[d][1,3]dioxol-5-yl)oxiran-2-yl)-2,3-dimethoxybenzoate; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 3h;

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h; Reagent/catalyst; diastereoselective reaction;
DOI:10.1021/acs.orglett.9b02715