Carbamic acid, [(1R)-1-(cyanomethyl)-3-hydroxypropyl]-, 1,1-dimethylethyl

Base Information

Chemical Name:Carbamic acid, [(1R)-1-(cyanomethyl)-3-hydroxypropyl]-, 1,1-dimethylethyl
CAS No.:211804-20-5
Molecular Formula:C₁₀H₁₈N₂O₃
Molecular Weight:214.265
Hs Code.:
Mol file:211804-20-5.mol

Synonyms:Carbamic acid, [(1R)-1-(cyanomethyl)-3-hydroxypropyl]-, 1,1-dimethylethyl

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [(1R)-1-(cyanomethyl)-3-hydroxypropyl]-, 1,1-dimethylethyl

Chemical Property:

Boiling Point:400.8±40.0 °C(Predicted)
PKA:11.43±0.46(Predicted)
PSA：82.35000
Density:1.086±0.06 g/cm3(Predicted)
LogP:1.56668

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of Carbamic acid, [(1R)-1-(cyanomethyl)-3-hydroxypropyl]-, 1,1-dimethylethyl

There total 1 articles about Carbamic acid, [(1R)-1-(cyanomethyl)-3-hydroxypropyl]-, 1,1-dimethylethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₂₄N₂O₆

: 211804-20-5
((R)-1-Cyanomethyl-3-hydroxy-propyl)-carbamic acid tert-butyl ester

Guidance literature:: With sodium tetrahydroborate; In water; at -15 ℃; Yield given;
DOI:10.1016/S0040-4039(98)01007-7

Reference yield:

: 211804-20-5
((R)-1-Cyanomethyl-3-hydroxy-propyl)-carbamic acid tert-butyl ester

: 211804-21-6
((R)-5-Bromo-3-tert-butoxycarbonylamino-pentyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: imidazole / 20 °C

2: CoCl₂*6H₂O, NaBH₄ / methanol / -15 °C

3: K₂CO₃ / dioxane

4: Bu₄NF / tetrahydrofuran / 20 °C

5: Ph₃P, CBr₄ / tetrahydrofuran / 20 °C

With 1H-imidazole; sodium tetrahydroborate; carbon tetrabromide; tetrabutyl ammonium fluoride; potassium carbonate; triphenylphosphine; cobalt(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1016/S0040-4039(98)01007-7

Reference yield:

: 211804-20-5
((R)-1-Cyanomethyl-3-hydroxy-propyl)-carbamic acid tert-butyl ester

: ((R)-3-tert-Butoxycarbonylamino-5-hydroxy-pentyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / 20 °C

2: CoCl₂*6H₂O, NaBH₄ / methanol / -15 °C

3: K₂CO₃ / dioxane

4: Bu₄NF / tetrahydrofuran / 20 °C

With 1H-imidazole; sodium tetrahydroborate; tetrabutyl ammonium fluoride; potassium carbonate; cobalt(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1016/S0040-4039(98)01007-7