tert-Butyl 2-amino-5-methylhexanoate

Base Information

• Chemical Name: tert-Butyl 2-amino-5-methylhexanoate
• CAS No.: 1543874-84-5
• Molecular Weight: 201.31
• Mol file: 1543874-84-5.mol

Synonyms:tert-Butyl 2-amino-5-methylhexanoate

Chemical Property of tert-Butyl 2-amino-5-methylhexanoate

Chemical Property:

• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl2-amino-5-methylhexanoate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-Butyl 2-amino-5-methylhexanoate

There total 3 articles about tert-Butyl 2-amino-5-methylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

tert-butyl 2-((diphenylmethylene)amino)-5-methylhexanoate → tert-butyl 2-amino-5-methylhexanoate (1543874-84-5)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; at 60 ℃;

DOI:10.1021/acs.joc.9b02810

Reference yield:

N-(diphenylmethylene)glycine tert-butyl ester (81477-94-3) → tert-butyl 2-amino-5-methylhexanoate (1543874-84-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetra(n-butyl)ammonium hydroxide; sodium hydroxide / dichloromethane; water / 12 h / 20 °C

2: hydroxylamine hydrochloride; pyridine / 60 °C

With pyridine; hydroxylamine hydrochloride; tetra(n-butyl)ammonium hydroxide; sodium hydroxide; In dichloromethane; water;

DOI:10.1021/acs.joc.9b02810

Reference yield:

isopentyl iodide (541-28-6) → tert-butyl 2-amino-5-methylhexanoate (1543874-84-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetra(n-butyl)ammonium hydroxide; sodium hydroxide / dichloromethane; water / 12 h / 20 °C

2: hydroxylamine hydrochloride; pyridine / 60 °C

With pyridine; hydroxylamine hydrochloride; tetra(n-butyl)ammonium hydroxide; sodium hydroxide; In dichloromethane; water;

DOI:10.1021/acs.joc.9b02810

upstream raw materials:

N-(diphenylmethylene)glycine tert-butyl ester

isopentyl iodide