1-Propylquinazolin-4(1H)-one

Base Information

• Chemical Name: 1-Propylquinazolin-4(1H)-one
• CAS No.: 3476-69-5
• Molecular Formula: C11H12N2O
• Molecular Weight: 188.22578
• Mol file: 3476-69-5.mol

Synonyms:1-Propylquinazolin-4(1H)-one

Chemical Property of 1-Propylquinazolin-4(1H)-one

Chemical Property:

• PSA: 34.89000
• LogP: 1.80650

Purity/Quality:

≥99% ^*data from raw suppliers

1-Propylquinazolin-4(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Propylquinazolin-4(1H)-one

There total 4 articles about 1-Propylquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(n-propylamino)benzoic acid (21716-81-4) + orthoformic acid triethyl ester (122-51-0) → 1-Propyl-1,4-dihydro-chinazol-4-on (3476-69-5)

Guidance literature:

With ammonium acetate; at 90 - 95 ℃; for 3h; neat (no solvent);

DOI:10.1080/00397911.2011.566407

Reference yield:

N-propylisatin (41042-12-0) → 1-Propyl-1,4-dihydro-chinazol-4-on (3476-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dihydrogen peroxide; sodium hydroxide / water / 30 °C / Cooling with ice

1.2: pH 5 - 6 / Cooling with ice

2.1: ammonium acetate / 3 h / 90 - 95 °C / neat (no solvent)

With ammonium acetate; dihydrogen peroxide; sodium hydroxide; In water;

DOI:10.1080/00397911.2011.566407

Reference yield:

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → 1-Propyl-1,4-dihydro-chinazol-4-on (3476-69-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide

2.1: dihydrogen peroxide; sodium hydroxide / water / 30 °C / Cooling with ice

2.2: pH 5 - 6 / Cooling with ice

3.1: ammonium acetate / 3 h / 90 - 95 °C / neat (no solvent)

With ammonium acetate; dihydrogen peroxide; potassium carbonate; sodium hydroxide; In water; N,N-dimethyl-formamide;

DOI:10.1080/00397911.2011.566407

upstream raw materials:

N-propylisatin

2-(n-propylamino)benzoic acid

orthoformic acid triethyl ester

indole-2,3-dione

Refernces