5,6-dihydro-4H-cyclopenta[d]isoxazole-3-carboxylic acid

Base Information

• Chemical Name: 5,6-dihydro-4H-cyclopenta[d]isoxazole-3-carboxylic acid
• CAS No.: 52482-09-4
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.13538
• Hs Code.: 2934999090
• Mol file: 52482-09-4.mol

Synonyms:5,6-dihydro-4H-cyclopenta[d]isoxazole-3-carboxylic acid

Chemical Property of 5,6-dihydro-4H-cyclopenta[d]isoxazole-3-carboxylic acid

Chemical Property:

• PSA: 58.89000
• LogP: 0.06150

Purity/Quality:

99% ^*data from raw suppliers

cis-4,5,6,6a-Tetrahydro-3aH-cyclopenta[d]isoxazole-3-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-dihydro-4H-cyclopenta[d]isoxazole-3-carboxylic acid

There total 3 articles about 5,6-dihydro-4H-cyclopenta[d]isoxazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-ethyl cis-3a,5,6,6a-tetrahydro-4H-cyclopentaisoxazole-3-carboxylate (52482-08-3) → cis-3a,5,6,6a-Tetrahydro-4H-cyclopentisoxazole-3-carboxylic acid (52482-09-4,176909-91-4)

Guidance literature:

With sodium hydroxide; at 5 ℃; for 0.75h;

Reference yield:

cyclopentene (142-29-0) → cis-3a,5,6,6a-Tetrahydro-4H-cyclopentisoxazole-3-carboxylic acid (52482-09-4,176909-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / diethyl ether

2: aq. NaOH / 0.75 h / 5 °C

With sodium hydroxide; triethylamine; In diethyl ether;

Reference yield:

cis-3a,5,6,6a-Tetrahydro-4H-cyclopentisoxazole-3-carbonitrile (83967-80-0) → cis-3a,5,6,6a-Tetrahydro-4H-cyclopentisoxazole-3-carboxylic acid (52482-09-4,176909-91-4)

Guidance literature:

With sodium hydroxide; 1.) reflux, 30 min., water, 2.) reflux, 1-2 h, water/ethanol;

DOI:10.1021/jo00151a017

upstream raw materials:

(+/-)-ethyl cis-3a,5,6,6a-tetrahydro-4H-cyclopentaisoxazole-3-carboxylate

cis-3a,5,6,6a-Tetrahydro-4H-cyclopentisoxazole-3-carbonitrile

cyclopentene

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