5-METHYL-7-PHENYL-4,5,6,7-TETRAHYDRO-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YLAMINE

Base Information

• Chemical Name: 5-METHYL-7-PHENYL-4,5,6,7-TETRAHYDRO-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YLAMINE
• CAS No.: 330833-68-6
• Molecular Formula: C12H15N5
• Molecular Weight: 229.285
• Hs Code.: 2933990090
• Mol file: 330833-68-6.mol

Synonyms:5-METHYL-7-PHENYL-4,5,6,7-TETRAHYDRO-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YLAMINE

Chemical Property of 5-METHYL-7-PHENYL-4,5,6,7-TETRAHYDRO-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YLAMINE

Chemical Property:

• PSA: 68.76000
• LogP: 2.37300

Purity/Quality:

98%min ^*data from raw suppliers

5-Methyl-7-phenyl-4,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHYL-7-PHENYL-4,5,6,7-TETRAHYDRO-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YLAMINE

There total 1 articles about 5-METHYL-7-PHENYL-4,5,6,7-TETRAHYDRO-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-amino-5-methyl-7-phenyl-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine (148612-47-9) → 2-amino-5-methyl-7-phenyl-4,5,6,7-tetrahydro-1,2,4-triazolo[1,5-a]pyrimidine (330833-68-6)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 50 - 60 ℃;

DOI:10.1134/S107042800805014X

Reference yield: 86.0%

2-amino-5-methyl-7-phenyl-4,5,6,7-tetrahydro-1,2,4-triazolo[1,5-a]pyrimidine (330833-68-6) + 4-chlorobenzoylmethyl bromide (536-38-9) → 2-amino-3-[2-(4-chlorophenyl)-2-oxoethyl]-5-methyl-7-phenyl-4,5,6,7-tetrahydro-3H-[1,2,4]triazolo[1,5-a]pyrimidin-8-ium bromide

Guidance literature:

In acetonitrile; for 4h; Reflux;

DOI:10.1016/j.tet.2015.06.059

Reference yield: 80.0%

2-amino-5-methyl-7-phenyl-4,5,6,7-tetrahydro-1,2,4-triazolo[1,5-a]pyrimidine (330833-68-6) + diethyl 2-ethoxymethylenemalonate (87-13-8) → diethyl 2-{[(5-methyl-7-phenyl-4,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)amino]methylene}malonate

Guidance literature:

In N,N-dimethyl-formamide; at 90 ℃; for 4h;

DOI:10.1016/j.tetlet.2017.01.030

upstream raw materials:

2-amino-5-methyl-7-phenyl-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine

Downstream raw materials:

2-methyl-8-oxo-4-phenyl-1,2,3,4,7,8,9,10-octahydro[1,2,4]triazolo[1,5-a:4,3-a']dipyrimidin-5-ium chloride

C₁₅H₁₈ClN₅O

2-methyl-8-oxo-4-phenyl-1,2,3,4,9,10-hexahydro-8H-[1,2,4]triazolo[1,5-a:4,3-a']dipyrimidin-5-ium-7-ide

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