BOC-3-CARBOXYMETHYL-1-PHENYL-1,3,8-TRIAZASPIRO[4 5]DECAN-4-ONE

Base Information

• Chemical Name: BOC-3-CARBOXYMETHYL-1-PHENYL-1,3,8-TRIAZASPIRO[4 5]DECAN-4-ONE
• CAS No.: 180386-35-0
• Molecular Formula: C20H27N3O5
• Molecular Weight: 389.451
• Hs Code.: 2933990090
• Mol file: 180386-35-0.mol

Synonyms:RARECHEM EM WB 0252;BOC-3-CARBOXYMETHYL-1-PHENYL-1,3,8-TRIAZASPIRO[4 5]DECAN-4-ONE;BOC-CPTD;BOC-CPTD-OH;2-(8-(tert-Butoxycarbonyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetic acid

Chemical Property of BOC-3-CARBOXYMETHYL-1-PHENYL-1,3,8-TRIAZASPIRO[4 5]DECAN-4-ONE

Chemical Property:

• PSA: 90.39000
• LogP: 2.08780
• Storage Temp.: Store at 0-5°C

Purity/Quality:

97% ^*data from raw suppliers

Boc-3-carboxymethyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-3-CARBOXYMETHYL-1-PHENYL-1,3,8-TRIAZASPIRO[4 5]DECAN-4-ONE

There total 8 articles about BOC-3-CARBOXYMETHYL-1-PHENYL-1,3,8-TRIAZASPIRO[4 5]DECAN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 2-(8-(tert-butoxycarbonyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetic acid (180386-35-0)

Guidance literature:

Multi-step reaction with 7 steps

1: AcOH / H₂O / 48 h / Ambient temperature

2: 90percent H₂SO₄ / 20 h

3: AcOH / toluene / 20 h / Heating

4: H₂, conc. aq. HCl / 5percent Pd/C / methanol / 96 h / 2327.2 Torr

5: Na₂CO₃ / H₂O; dioxane / 20 h / Ambient temperature

6: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h

7: Na₂CO₃ / methanol; H₂O / 3 h / Heating

With hydrogenchloride; sulfuric acid; hydrogen; sodium hydride; sodium carbonate; acetic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; water; toluene;

DOI:10.1021/jm950676i

Reference yield:

1-benzyl-4-(phenylamino)piperidine-4-carbonitrile (968-86-5) → 2-(8-(tert-butoxycarbonyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetic acid (180386-35-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 90percent H₂SO₄ / 20 h

2: AcOH / toluene / 20 h / Heating

3: H₂, conc. aq. HCl / 5percent Pd/C / methanol / 96 h / 2327.2 Torr

4: Na₂CO₃ / H₂O; dioxane / 20 h / Ambient temperature

5: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h

6: Na₂CO₃ / methanol; H₂O / 3 h / Heating

With hydrogenchloride; sulfuric acid; hydrogen; sodium hydride; sodium carbonate; acetic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; water; toluene;

DOI:10.1021/jm950676i

Reference yield:

1-benzyl-4-phenylaminopiperidine-4-carboxylic acid amide (1096-03-3) → 2-(8-(tert-butoxycarbonyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetic acid (180386-35-0)

Guidance literature:

Multi-step reaction with 5 steps

1: AcOH / toluene / 20 h / Heating

2: H₂, conc. aq. HCl / 5percent Pd/C / methanol / 96 h / 2327.2 Torr

3: Na₂CO₃ / H₂O; dioxane / 20 h / Ambient temperature

4: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h

5: Na₂CO₃ / methanol; H₂O / 3 h / Heating

With hydrogenchloride; hydrogen; sodium hydride; sodium carbonate; acetic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; water; toluene;

DOI:10.1021/jm950676i

upstream raw materials:

tert-butyl 3-(2-methoxy-2-oxo-ethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

1-phenylmethyl-4-piperidone

8-(tert-Butoxycarbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

1-benzyl-4-(phenylamino)piperidine-4-carbonitrile

Downstream raw materials:

tert-butyl 3-(2-methoxy-2-oxo-ethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

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