Velpatasvir intermediate

Base Information

Chemical Name:Velpatasvir intermediate
CAS No.:1378391-44-6
Molecular Formula:C44H55N7O7
Molecular Weight:793.963
Hs Code.:

Synonyms:Velpatasvir intermediate;tert-butyl (2S,4S)-2-[5-(2-{(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl}-1,4,5,11-tetrahydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine-1-carboxylate;Velpatasvir intermediate N-3;intermediate of Velpatasvir

Suppliers and Price of Velpatasvir intermediate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 25 raw suppliers

Chemical Property of Velpatasvir intermediate

Chemical Property:

Boiling Point:1044.9±65.0 °C(Predicted)
PKA:11.22±0.46(Predicted)
PSA：164.00000
Density:1.261±0.06 g/cm3(Predicted)
LogP:7.76860

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Velpatasvir intermediate

There total 14 articles about Velpatasvir intermediate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: C₄₄H₅₅N₅O₁₀

: 1378391-44-6
tert-butyl (2S,4S)-2-[5-(2-{(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl}-1,4,5,11-tetrahydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: With ammonium acetate; In 2-methoxy-ethanol; toluene; at 90 - 95 ℃;

Reference yield: 84.0%

: 1378391-43-5
(2R,4R)-1-tert-butyl 2-(2-(9-((2S,5S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carbonyloxy)-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate

: 1378391-44-6
tert-butyl (2S,4S)-2-[5-(2-{(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl}-1,4,5,11-tetrahydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: With ammonium acetate; In 2-methoxy-ethanol; toluene; at 110 ℃; for 4.5h;

Reference yield:

: 1378388-16-9
(2S,4S)-N-(tert-butyloxycarbonyl)-4-(methoxymethyl)-pyrrolidine-2-carboxylic acid

: 1378391-44-6
tert-butyl (2S,4S)-2-[5-(2-{(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl}-1,4,5,11-tetrahydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / 4 h / 20 °C

2: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C

3: caesium carbonate / 20 h / 50 °C

4: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C

With pyridinium hydrobromide perbromide; ammonium acetate; caesium carbonate; In methanol; dichloromethane; 2-methoxy-ethanol; toluene;