5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime

Base Information

• Chemical Name: 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
• CAS No.: 861214-33-7
• Molecular Formula: C₁₆H₁₀FN₃O₂
• Molecular Weight: 295.273
• Mol file: 861214-33-7.mol

Synonyms:5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime;5'-Fluoroindirubinoxime;-Fluoroindirubinoxime

Chemical Property of 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime

Chemical Property:

• PSA: 77.21000
• LogP: 3.01600
• Storage Temp.: Store at +4°C

Purity/Quality:

97% ^*data from raw suppliers

5’-Fluoroindirubinoxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5’-Fluoroindirubinoxime is an antiproliferative agent and an inhibitor of FLT3.

Technology Process of 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime

There total 11 articles about 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-Fluoroindirubin (910035-37-9) → (2Z,3E)-5'-fluoro-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one (861214-33-7)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; at 110 ℃; for 0.166667h; microwave irradiation;

DOI:10.1016/j.bmc.2006.05.036

Reference yield: 54.4%

5-Fluoroindirubin (910035-37-9) → 5-fluoroindirubin-3'-oxime (861214-33-7)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; at 120 ℃;

DOI:10.1016/j.bmc.2005.08.008

Reference yield:

5-fluoro-1H-indole-2,3-dione (443-69-6) → (2Z,3E)-5'-fluoro-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one (861214-33-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / Na₂CO₃ / methanol / 3 h / 20 °C

2: 90 percent / pyridine; hydroxylamine hydrochloride / 0.17 h / 110 °C / microwave irradiation

With pyridine; hydroxylamine hydrochloride; sodium carbonate; In methanol;

DOI:10.1016/j.bmc.2006.05.036

upstream raw materials:

5-Fluoroindirubin

5-fluoro-1H-indole-2,3-dione

3-indoxyl acetate

2-bromobenzoic-acid

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