1-METHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE

Base Information

• Chemical Name: 1-METHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE
• CAS No.: 525-40-6
• Molecular Formula: C₁₂H₁₄N₂
• Molecular Weight: 186.257
• Mol file: 525-40-6.mol

Synonyms:TETRAHYDROHARMAN;TIMTEC-BB SBB007400;1-METHYL-2,3,4,9-TETRAHYDRO-1 H-B-CARBOLINE;1-METHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE;AKOS JY2082745;ELEAGNIN, DL-;DL-ELEAGNIN;DL-TETRAHYDROHARMAN

Chemical Property of 1-METHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE

Chemical Property:

• Melting Point: 179-180°C
• Boiling Point: 362.6oC at 760 mmHg
• Flash Point: 173.1oC
• PSA: 27.82000
• Density: 1.13 g/cm3
• LogP: 2.70340

Purity/Quality:

98%min ^*data from raw suppliers

1-METHYL-2,3,4,9-TETRAHYDRO-1H-ALPHA-CARBOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-METHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE

There total 27 articles about 1-METHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-methyl-4,9-dihydro-3H-β-carboline (525-41-7) → (R)-1-methyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole (525-40-6,2506-10-7,23844-21-5,2254-36-6)

Guidance literature:

With formic acid; (S,S)-TsDPEN-Ru(II); triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol9011772

Reference yield: 93.0%

eleagnine (2506-10-7) → (R)-1-methyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole (525-40-6,2506-10-7,23844-21-5,2254-36-6)

Guidance literature:

With hydrogenchloride; borane-ammonia complex; In aq. phosphate buffer; N,N-dimethyl-formamide; at 37 ℃; for 24h; pH=7.8;

DOI:10.1021/ja4051235

Reference yield: 85.0%

C16H18N2O2 → (R)-1-methyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole (525-40-6,2506-10-7,23844-21-5,2254-36-6)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; formic acid; triphenylphosphine; In tetrahydrofuran; at 40 ℃; for 2h; Reagent/catalyst;

DOI:10.1016/j.tetasy.2017.10.019

upstream raw materials:

1-methyl-4,9-dihydro-3H-β-carboline

((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-((S)-9-methoxymethyl-1-methyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-meth-(E)-ylidene]-amine

tetrahydrobetacarboline

(S)-β-carboline-O-tert-butylvalinol formamidine