(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN

Base Information

• Chemical Name: (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN
• CAS No.: 1000578-26-6
• Molecular Formula: C18H25N3
• Molecular Weight: 283.4112
• Mol file: 1000578-26-6.mol

Synonyms:AS 19;(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN

Chemical Property of (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN

Chemical Property:

• PSA: 21.06000
• LogP: 3.12280
• Storage Temp.: Desiccate at -20°C
• Solubility.: <28.34mg/ml in ethanol; <28.34mg/ml in DMSO

Purity/Quality:

98%Min ^*data from raw suppliers

AS 19 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A potent 5-HT7 receptor agonist

Technology Process of (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN

There total 2 articles about (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(6R)-6-(Dimethylamino)-5,6,7,8-tetrahydronaphthalen-1-yl trifluoromethanesulfonate (1063665-66-6) + 1,3,5-trimethylpyrazole-4-boronic acid pinacol ester (844891-04-9) → (2S)-(+)-5-(1,3,5-trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin (1063664-72-1,1000578-26-6)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 2h; Heating / reflux;

Reference yield:

→ N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-naphthalen-2-amine (1063664-85-6,1000578-26-6)

Guidance literature:

upstream raw materials:

(6R)-6-(Dimethylamino)-5,6,7,8-tetrahydronaphthalen-1-yl trifluoromethanesulfonate

1,3,5-trimethylpyrazole-4-boronic acid pinacol ester

Refernces

• 1、 -. "Combination of a 5-HT7 receptor ligand and an opioid receptor ligand". Page/Page column 56. . Retrieved 2009/01/20.