1-(Cyclopentylcarbonyl)-3-piperidine-carboxylic acid

Base Information

• Chemical Name: 1-(Cyclopentylcarbonyl)-3-piperidine-carboxylic acid
• CAS No.: 926227-70-5
• Molecular Formula: C₁₂H₁₉NO₃
• Molecular Weight: 225.288
• Hs Code.: 2933399090
• Mol file: 926227-70-5.mol

Synonyms:1-(Cyclopentylcarbonyl)-3-piperidine-carboxylic acid;1-(cyclopentanecarbonyl)nipecotic acid;1-(cyclopentanecarbonyl)piperidine-3-carboxylic acid;1-(cyclopentyl-oxomethyl)-3-piperidinecarboxylic acid;BBV-004577

Chemical Property of 1-(Cyclopentylcarbonyl)-3-piperidine-carboxylic acid

Chemical Property:

• Boiling Point: 433.1±38.0 °C(Predicted)
• PKA: 4.38±0.20(Predicted)
• PSA: 57.61000
• Density: 1.212±0.06 g/cm3(Predicted)
• LogP: 1.43770

Purity/Quality:

98%min ^*data from raw suppliers

1-(Cyclopentylcarbonyl)-3-piperidine-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(Cyclopentylcarbonyl)-3-piperidine-carboxylic acid

There total 3 articles about 1-(Cyclopentylcarbonyl)-3-piperidine-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C14H23NO3 → C12H19NO3 (926227-70-5)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 18 ℃; for 2h;

Reference yield:

(R)-ethyl nipecotate (25137-01-3) → C12H19NO3 (926227-70-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 15 h / 18 °C / Inert atmosphere

2: lithium hydroxide monohydrate; water / tetrahydrofuran / 2 h / 18 °C

With 4-methyl-morpholine; lithium hydroxide monohydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

Reference yield:

cyclopentanecarboxylic acid (3400-45-1) → C12H19NO3 (926227-70-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 15 h / 18 °C / Inert atmosphere

2: lithium hydroxide monohydrate; water / tetrahydrofuran / 2 h / 18 °C

With 4-methyl-morpholine; lithium hydroxide monohydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

upstream raw materials:

(R)-ethyl nipecotate

cyclopentanecarboxylic acid

Refernces