methyl 3-amino-6-methyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate

Base Information

• Chemical Name: methyl 3-amino-6-methyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate
• CAS No.: 313379-68-9
• Molecular Formula: C₁₁H₉F₃N₂O₂S
• Molecular Weight: 290.266
• Hs Code.: 2934999090
• Mol file: 313379-68-9.mol

Synonyms:methyl 3-amino-6-methyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate;3-Amino-6-methyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylic acid methyl ester

Chemical Property of methyl 3-amino-6-methyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate

Chemical Property:

• PSA: 93.45000
• LogP: 3.57350

Purity/Quality:

99% ^*data from raw suppliers

Methyl 3-amino-6-methyl-4-(trifluoromethyl)-thieno[2,3-b]pyridine-2-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-amino-6-methyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate

There total 3 articles about methyl 3-amino-6-methyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl chloroacetate (96-34-4) + 6-methyl-2-thioxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (182127-92-0) → methyl 3-amino-6-methyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate (313379-68-9)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2019.03.060

Reference yield:

1,1,1-Trifluoro-2,4-pentanedione (367-57-7) → methyl 3-amino-6-methyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate (313379-68-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / ethanol / 6 h / Reflux

2: sodium methylate / methanol / 3 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; sodium methylate; In methanol; ethanol;

DOI:10.1016/j.ejmech.2019.03.060

Reference yield:

→ methyl 3-amino-6-methyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate (313379-68-9)

Guidance literature:

With potassium hydroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 3h;

upstream raw materials:

methyl chloroacetate

6-methyl-2-thioxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

1,1,1-Trifluoro-2,4-pentanedione

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