Alanine, N-methyl-N-(2-methyl-1-thioxopropyl)-, ethyl ester

Base Information

Chemical Name:Alanine, N-methyl-N-(2-methyl-1-thioxopropyl)-, ethyl ester
CAS No.:445395-83-5
Molecular Formula:C₁₀H₁₉NO₂S
Molecular Weight:217.332
Hs Code.:
Mol file:445395-83-5.mol

Synonyms:Alanine, N-methyl-N-(2-methyl-1-thioxopropyl)-, ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Alanine, N-methyl-N-(2-methyl-1-thioxopropyl)-, ethyl ester

Chemical Property:

PSA：61.63000
LogP:1.85320

Purity/Quality:

Safty Information:

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Technology Process of Alanine, N-methyl-N-(2-methyl-1-thioxopropyl)-, ethyl ester

There total 2 articles about Alanine, N-methyl-N-(2-methyl-1-thioxopropyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 445395-81-3
ethyl (R/S)-N-methyl-N-(2-methylpropanoyl)alaninate

: 445395-83-5
ethyl (R/S)-N-methyl-N-(2-methylpropanethioyl)alaninate

Guidance literature:: With Davy reagent; In pyridine; toluene; at 100 ℃; for 17h;
DOI:10.1002/1522-2675(200203)85:3<885::AID-HLCA885>3.0.CO;2-Z

Reference yield:

: 78130-90-2
ethyl (S)-N-(2-methylpropanoyl)alaninate

: 445395-83-5
ethyl (R/S)-N-methyl-N-(2-methylpropanethioyl)alaninate

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / NaH; LiClO₄ / tetrahydrofuran / 5 h / 20 - 40 °C

2: 50 percent / Davy reagent / toluene; pyridine / 17 h / 100 °C

With Davy reagent; lithium perchlorate; sodium hydride; In tetrahydrofuran; pyridine; toluene;
DOI:10.1002/1522-2675(200203)85:3<885::AID-HLCA885>3.0.CO;2-Z

Reference yield:

: 445395-83-5
ethyl (R/S)-N-methyl-N-(2-methylpropanethioyl)alaninate

: 445396-01-0
ethyl N-[(benzyloxy)carbonyl]-(S)-phenylalanyl-dimethylglycyl-(R/S)-N-methylalaninate

Guidance literature:: Multi-step reaction with 3 steps

1.1: DMF; COCl₂ / CH₂Cl₂; toluene / 1 h / 0 - 20 °C

1.2: 1,4-diazabicyclo[2.2.2]octane / tetrahydrofuran / 0.33 h / 20 °C

2.1: 52 percent / NaN₃ / tetrahydrofuran / 5 h / 20 °C

3.1: 70 percent / diethyl ether / 1 h / 20 °C

With sodium azide; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1002/1522-2675(200203)85:3<885::AID-HLCA885>3.0.CO;2-Z