(R)-3-AMINO-3-(4-CHLORO-PHENYL)-PROPAN-1-OL

Base Information

• Chemical Name: (R)-3-AMINO-3-(4-CHLORO-PHENYL)-PROPAN-1-OL
• CAS No.: 1213362-28-7
• Molecular Formula: C9H12ClNO
• Molecular Weight: 185.65
• Hs Code.: 2922199090
• Mol file: 1213362-28-7.mol

Synonyms:(R)-BETA-(4-CHLOROPHENYL)ALANINOL;(R)-3-AMINO-3-(4-CHLORO-PHENYL)-PROPAN-1-OL;(gammaR)-gamma-Amino-4-chlorobenzenepropanol

Chemical Property of (R)-3-AMINO-3-(4-CHLORO-PHENYL)-PROPAN-1-OL

Chemical Property:

• PSA: 46.25000
• LogP: 2.42250

Purity/Quality:

97% ^*data from raw suppliers

(R)-3-(4-Chlorophenyl)-β-alaninol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-AMINO-3-(4-CHLORO-PHENYL)-PROPAN-1-OL

There total 6 articles about (R)-3-AMINO-3-(4-CHLORO-PHENYL)-PROPAN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(S)-β-amino-β-(4-chlorophenyl)propionic acid (131690-60-3,131690-61-4) → (3S)-3-amino-3-(4-chlorophenyl)propan-1-ol (1213362-28-7,886061-26-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1002/chem.200501261

Reference yield: 57.0%

3-amino-3-(4-chlorophenyl)propionic acid (19947-39-8,131690-61-4) → 3-amino-3-(4-chlorophenyl)propan-1-ol (68208-26-4,1213362-28-7,886061-26-3)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 22 ℃; for 5.83333h; Inert atmosphere;

DOI:10.1021/jm301762v

Reference yield:

C11H11Cl4NO → 3-amino-3-(4-chlorophenyl)propan-1-ol (68208-26-4,1213362-28-7,886061-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: cesium iodide; phthaloyl peroxide / acetonitrile / 8 h / Irradiation; Inert atmosphere

2: hydrogenchloride / methanol; water / 2 h

With hydrogenchloride; phthaloyl peroxide; cesium iodide; In methanol; water; acetonitrile;

DOI:10.1002/anie.202008806

upstream raw materials:

3-amino-3-(4-chlorophenyl)propionic acid

4-chlorobenzaldehyde

(S)-β-amino-β-(4-chlorophenyl)propionic acid

Downstream raw materials:

3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propyl Methanesulfonate

tert-butyl 1-(4-chlorophenyl)-3-sulfamoylpropylcarbamate

3-amino-3-(4-chlorophenyl)propane-1-sulfonamide

tert-butyl 1-(4-chlorophenyl)-3-(dimethylamino)propylcarbamate