Chemical Property of SB-218078
Chemical Property:
- PSA：69.02000
- Density:1.8g/cm3
- LogP:4.36310
- Storage Temp.:Store at RT
- Solubility.:≤5mg/ml in DMSO;5mg/ml in dimethyl formamide
- XLogP3:3.8
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:0
- Exact Mass:393.11134135
- Heavy Atom Count:30
- Complexity:754
- Purity/Quality:
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98% *data from raw suppliers
SB218078 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C1O2)C7=C53)C(=O)NC6=O
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Description
SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that blocks phosphorylation of cdc25 with an IC50 value of 15 nM. It less potently inhibits cdc2 and PKC (IC50s = 250 and 1,000 nM, respectively) and causes 85% inhibition of PKD1 at 1 μM. SB 218078 releases G2 cell cycle arrest induced by γ-irradiation or the topoisomerase I inhibitor topotecan . In this way, SB 218078 enhances the cytotoxicity of DNA-damaging compounds.
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Uses
SB 218078 is a selective inhibitor of Chk1.
