ETHYL 4-(2,6-DIFLUOROPHENYL)-4-OXOBUTYRATE

Base Information

• Chemical Name: ETHYL 4-(2,6-DIFLUOROPHENYL)-4-OXOBUTYRATE
• CAS No.: 493004-53-8
• Molecular Formula: C12H12F2O3
• Molecular Weight: 242.222
• Hs Code.: 2918300090
• Mol file: 493004-53-8.mol

Synonyms:ETHYL 4-(2,6-DIFLUOROPHENYL)-4-OXOBUTYRATE

Chemical Property of ETHYL 4-(2,6-DIFLUOROPHENYL)-4-OXOBUTYRATE

Chemical Property:

• Vapor Pressure: 0.000335mmHg at 25°C
• Boiling Point: 319.6°C at 760 mmHg
• Flash Point: 142.3°C
• PSA: 43.37000
• Density: 1.217g/cm³
• LogP: 2.49080

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-(2,6-difluorophenyl)-4-oxobutyrate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-(2,6-DIFLUOROPHENYL)-4-OXOBUTYRATE

There total 1 articles about ETHYL 4-(2,6-DIFLUOROPHENYL)-4-OXOBUTYRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-(2,6-difluorophenyl)-4-oxobut-2-ynoic acid ethyl ester (493004-52-7) → C12H12F2O3 (493004-53-8)

Guidance literature:

4-(2,6-difluorophenyl)-4-oxobut-2-ynoic acid ethyl ester; With tributyl-amine; In DMF (N,N-dimethyl-formamide); at 60 ℃; for 3h;

With formic acid; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; for 1h;

Reference yield:

C12H12F2O3 (493004-53-8) → 4-(2,6-difluorophenyl)-4-oxobutyric acid (478162-62-8)

Guidance literature:

With lithium hydroxide; water; In tetrahydrofuran;

upstream raw materials:

4-(2,6-difluorophenyl)-4-oxobut-2-ynoic acid ethyl ester

Downstream raw materials:

4-(2,6-difluorophenyl)-4-oxobutyric acid

Refernces