(2S)-N,N-DIMETHYL-2-PIPERIDINEMETHANAMINE

Base Information

• Chemical Name: (2S)-N,N-DIMETHYL-2-PIPERIDINEMETHANAMINE
• CAS No.: 112419-07-5
• Molecular Formula: C8H18N2
• Molecular Weight: 142.244
• Mol file: 112419-07-5.mol

Synonyms:(2S)-N,N-DIMETHYL-2-PIPERIDINEMETHANAMINE;(2S)-N,N-Dimethyl-2-piperidinemethanamine 2HCl

Chemical Property of (2S)-N,N-DIMETHYL-2-PIPERIDINEMETHANAMINE

Chemical Property:

• PSA: 15.27000
• LogP: 1.01890

Purity/Quality:

99.90% ^*data from raw suppliers

(2S)-N,N-Dimethyl-2-piperidinemethanamine2HCl 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S)-N,N-DIMETHYL-2-PIPERIDINEMETHANAMINE

There total 4 articles about (2S)-N,N-DIMETHYL-2-PIPERIDINEMETHANAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-Piperidine-2-carboxylic acid dimethylamide (130497-29-9,701906-91-4,773047-06-6) → Dimethyl-(S)-1-piperidin-2-ylmethyl-amine (112419-07-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 30 ℃; for 3h;

DOI:10.1021/jm00105a061

Reference yield:

(S)-Piperidine-2-carbonyl chloride (741633-48-7) → Dimethyl-(S)-1-piperidin-2-ylmethyl-amine (112419-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / -5 °C

2: LiAlH₄ / tetrahydrofuran / 3 h / 30 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00105a061

Reference yield:

(S)-1-(ethoxycarbonyl)pipecolic acid (136598-30-6) → Dimethyl-(S)-1-piperidin-2-ylmethyl-amine (112419-07-5)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / CH₂Cl₂ / 24 h / Ambient temperature

2: CH₂Cl₂ / -5 °C

3: LiAlH₄ / tetrahydrofuran / 3 h / 30 °C

With lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00105a061

upstream raw materials:

(S)-Piperidine-2-carboxylic acid dimethylamide

(S)-Piperidine-2-carbonyl chloride

(S)-1-(ethoxycarbonyl)pipecolic acid

pipecolinic acid

Downstream raw materials:

2-(3,4-Dichloro-phenyl)-1-((S)-2-dimethylaminomethyl-piperidin-1-yl)-ethanone