Cdk4 Inhibitor

Base Information

• Chemical Name: Cdk4 Inhibitor
• CAS No.: 546102-60-7
• Molecular Weight: 0
• UNII: XZ73ATU8W7
• DSSTox Substance ID: DTXSID00416208
• Wikidata: Q27075825
• Pharos Ligand ID: 4TS97F4KZSVZ
• ChEMBL ID: CHEMBL64758
• Mol file: 546102-60-7.mol

Synonyms:Cdk4 Inhibitor;546102-60-7;K00024;Indolocarbazole deriv. 4(d);2-Bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione;XZ73ATU8W7;K00024 (cdk4 inhibitor);6-bromo-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17,19,21-nonaene-12,14-dione;K-00024;2-Bromo-12,13-dihydro-5H-indolo(2,3-a)pyrrolo(3,4-C)carbazole-5,7(6H)-dione;5H-Indolo(2,3-a)pyrrolo(3,4-C)carbazole-5,7(6H)-dione, 2-bromo-12,13-dihydro-;Cd4k Inhibitor;CDK4;D0D5HQ;UNII-XZ73ATU8W7;CHEMBL64758;BDBM6860;GTPL5950;SCHEMBL1395043;DTXSID00416208;HMS3229E04;AKOS016370155;CCG-206828;Q27075825;6-bromo-3,13,23-triazahexacyclo[14.7.0.0;{2,10}.0;{4,9}.0;{11,15}.0;{17,22}]tricosa-1(16),2(10),4(9),5,7,11(15),17(22),18,20-nonaene-12,14-dione;6-bromo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaene-12,14-dione

Chemical Property of Cdk4 Inhibitor

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 402.99564
• Heavy Atom Count: 26
• Complexity: 657

Purity/Quality:

≥90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=C4C(=C5C6=C(C=C(C=C6)Br)NC5=C3N2)C(=O)NC4=O

Technology Process of Cdk4 Inhibitor

There total 1 articles about Cdk4 Inhibitor which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-(6-bromo-1H-indol-3-yl)-3-(1H-indol-3-yl)-maleinimide (546102-48-1) → Cdk4 Inhibitor (546102-60-7)

Guidance literature:

With toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; for 5h; Heating;

DOI:10.1021/jm0256169

upstream raw materials:

2-(6-bromo-1H-indol-3-yl)-3-(1H-indol-3-yl)-maleinimide