4-(aminomethyl)cyclohexanone

Base Information

• Chemical Name: 4-(aminomethyl)cyclohexanone
• CAS No.: 934475-93-1
• Molecular Formula: C₇H₁₃NO
• Molecular Weight: 127.186
• Mol file: 934475-93-1.mol

Synonyms:4-(aminomethyl)cyclohexanone;Cyclohexanone, 4-(aminomethyl)-

Chemical Property of 4-(aminomethyl)cyclohexanone

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: DMSO (Sparingly, Sonicated), Methanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

4-(Aminomethyl)cyclohexanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(Aminomethyl)-cyclohexanone Hydrochloride is used to prepare dispiro-1,2,4-trioxolanes with antimalarial activities. It is also used to synthesize aminopyrimidines as SYK inhibitors useful in the treatment of SYK-mediated diseases.

Technology Process of 4-(aminomethyl)cyclohexanone

There total 1 articles about 4-(aminomethyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methoxy-2-aza-bicyclo[2.2.2]octane (30545-58-5) → 4-Aminomethyl-cyclohexanone (934475-93-1)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/jo00818a030

Reference yield:

4-Aminomethyl-cyclohexanone (934475-93-1) → 4-({[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}methyl)cyclohex-1-en-1-yl trifluoromethanesulfonate (1093685-26-7)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine

2: 2,6-dimethylpyridine

With 2,6-dimethylpyridine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;

DOI:10.1016/j.bmcl.2011.02.049

Reference yield:

4-Aminomethyl-cyclohexanone (934475-93-1) → C35H37N3O2 (1093685-70-1)

Guidance literature:

Multi-step reaction with 3 steps

1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine

2: 2,6-dimethylpyridine

3: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate

With 2,6-dimethylpyridine; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 3: Suzuki cross-coupling;

DOI:10.1016/j.bmcl.2011.02.049

upstream raw materials:

1-methoxy-2-aza-bicyclo[2.2.2]octane

Downstream raw materials:

4-({[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}methyl)cyclohex-1-en-1-yl trifluoromethanesulfonate

C₃₅H₃₇N₃O₂

C₃₂H₂₈F₃N₃O₂

C₃₂H₂₈F₃N₃O₂