Methyl ((S)-1-((S)-2-(4-(4-broMophenyl)-1H-iMidazol-2-yl)pyrrolidin-1-yl)-3-Methyl-1-oxobutan-2-yl)carbaMate

Base Information

• Chemical Name: Methyl ((S)-1-((S)-2-(4-(4-broMophenyl)-1H-iMidazol-2-yl)pyrrolidin-1-yl)-3-Methyl-1-oxobutan-2-yl)carbaMate
• CAS No.: 1228552-27-9
• Molecular Formula: C20H25BrN4O3
• Molecular Weight: 449.347
• Mol file: 1228552-27-9.mol

Synonyms:Methyl ((S)-1-((S)-2-(4-(4-broMophenyl)-1H-iMidazol-2-yl)pyrrolidin-1-yl)-3-Methyl-1-oxobutan-2-yl)carbaMate;methyl(R)-1-((R)-2-(2-(4-bromophenyl)-1H-imidazol-5-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate;((S)-1-{(S)-2-[5-(4-bromophenyl)-1H-imidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Chemical Property of Methyl ((S)-1-((S)-2-(4-(4-broMophenyl)-1H-iMidazol-2-yl)pyrrolidin-1-yl)-3-Methyl-1-oxobutan-2-yl)carbaMate

Chemical Property:

• PSA: 87.32000
• LogP: 4.21210

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl ((S)-1-((S)-2-(4-(4-broMophenyl)-1H-iMidazol-2-yl)pyrrolidin-1-yl)-3-Methyl-1-oxobutan-2-yl)carbaMate

There total 25 articles about Methyl ((S)-1-((S)-2-(4-(4-broMophenyl)-1H-iMidazol-2-yl)pyrrolidin-1-yl)-3-Methyl-1-oxobutan-2-yl)carbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S)-5-(4-bromophenyl)-2-(pyrrolidin-2-yl)-1H-imidazole (1255936-24-3) + N-methoxycarbonyl-L-valine (111398-44-8,74761-42-5) → ((S)-1-{(S)-2-[5-(4-bromophenyl)-1H-imidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester (1228552-27-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 91.8%

(S)-5-(4-bromophenyl)-2-(pyrrolidin-2-yl)-1H-imidazole dihydrochloride + N-methoxycarbonyl-L-valine (111398-44-8,74761-42-5) → ((S)-1-{(S)-2-[5-(4-bromophenyl)-1H-imidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester (1228552-27-9)

Guidance literature:

(S)-5-(4-bromophenyl)-2-(pyrrolidin-2-yl)-1H-imidazole dihydrochloride; N-methoxycarbonyl-L-valine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 1.75h;

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 14h;

Reference yield: 76.0%

(S)-5-(4-bromophenyl)-2-(pyrrolidin-2-yl)-1H-imidazole (1255936-24-3) + N-methoxycarbonyl-L-valine (111398-44-8,74761-42-5) → ((S)-1-{(S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester (1228552-27-9)

Guidance literature:

N-methoxycarbonyl-L-valine; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.166667h;

(S)-5-(4-bromophenyl)-2-(pyrrolidin-2-yl)-1H-imidazole; In dichloromethane; at 20 ℃; Inert atmosphere;

upstream raw materials:

(S)-5-(4-bromophenyl)-2-(pyrrolidin-2-yl)-1H-imidazole

N-methoxycarbonyl-L-valine

L-valine

1-(tert-butoxycarbonyl)-L-proline

Downstream raw materials:

[(S)-2-methyl-1-((S)-2-{5-[4-(4,4,5,5 tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-propyl]-carbamic acid methyl ester

[(S)-1-((S)-2-{4-[2-(4-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-phenyl)-quinolin-6-yl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid methyl ester

methyl {(2S)-1-[(2S)-2-{5-[4-(2-chloroquinolin-6-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

methyl {(2S)-1-[(2S)-2-{5-[4-(6-bromo-4-cyanoquinolin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate