N,N-diethylpiperidine-2-carboxamide

Base Information

• Chemical Name: N,N-diethylpiperidine-2-carboxamide
• CAS No.: 130497-30-2
• Molecular Formula: C10H20N2O
• Molecular Weight: 184.282
• DSSTox Substance ID: DTXSID401293379
• Mol file: 130497-30-2.mol

Synonyms:N,N-diethylpiperidine-2-carboxamide;130497-30-2;N,N-DIETHYL-2-PIPERIDINECARBOXAMIDE;SCHEMBL4153806;2-diethylaminocarbonyl-piperidine;DTXSID401293379;AKOS000166426

Chemical Property of N,N-diethylpiperidine-2-carboxamide

Chemical Property:

• PSA: 32.34000
• LogP: 1.32570
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 184.157563266
• Heavy Atom Count: 13
• Complexity: 166

Purity/Quality:

98%min ^*data from raw suppliers

N,N-Diethyl-2-piperidinecarboxamide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCN(CC)C(=O)C1CCCCN1

Technology Process of N,N-diethylpiperidine-2-carboxamide

There total 6 articles about N,N-diethylpiperidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H28N2O3 → N,N-diethylpiperidine-2-carboxamide (130497-30-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2008.03.078

Reference yield:

(S)-1-(ethoxycarbonyl)pipecolic acid (136598-30-6) → (S)-N,N-diethylpiperidine-2-carboxamide (130497-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂ / 24 h / Ambient temperature

2: CH₂Cl₂ / -5 °C

With thionyl chloride; In dichloromethane;

DOI:10.1021/jm00105a061

Reference yield:

pipecolinic acid (3105-95-1,83680-83-5) → (S)-N,N-diethylpiperidine-2-carboxamide (130497-30-2)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH / H₂O / 0 °C

2: SOCl₂ / CH₂Cl₂ / 24 h / Ambient temperature

3: CH₂Cl₂ / -5 °C

With sodium hydroxide; thionyl chloride; In dichloromethane; water;

DOI:10.1021/jm00105a061

upstream raw materials:

pyridine-2-carboxylic acid diethylamide; hydrochloride

(S)-Piperidine-2-carbonyl chloride

diethylamine

(S)-1-(ethoxycarbonyl)pipecolic acid

Downstream raw materials:

D,L-2-[(diethylamino)methyl]piperidine

Diethyl-(S)-1-piperidin-2-ylmethyl-amine

2-(3,4-Dichloro-phenyl)-1-((S)-2-diethylaminomethyl-piperidin-1-yl)-ethanone