7-methoxy-2-methyl-1H-indole

Base Information

• Chemical Name: 7-methoxy-2-methyl-1H-indole
• CAS No.: 53512-46-2
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Hs Code.: 2933990090
• Mol file: 53512-46-2.mol

Synonyms:2-methyl-7-methoxyindole;7-methoxy-2-methyl-indole;2-Methyl-7-methoxy 1H-indole;7-Methoxy-2-methyl-indol;2-Methyl-7-methoxyindol;

Chemical Property of 7-methoxy-2-methyl-1H-indole

Chemical Property:

• Vapor Pressure: 0.00123mmHg at 25°C
• Melting Point: 83-84℃
• Boiling Point: 308.5°Cat760mmHg
• Flash Point: 113.1°C
• PSA: 25.02000
• Density: 1.134g/cm³
• LogP: 2.48490
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

7-Methoxy-2-methyl-1H-indole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-methoxy-2-methyl-1H-indole

There total 19 articles about 7-methoxy-2-methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 4-methoxy-1H-indole-2-carboxylate (111258-23-2) → 2-methyl-7-methoxy indole (53512-46-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; 1,4-dioxane; at 0 ℃; for 16h; Reflux;

Reference yield: 77.0%

C17H17NO3S (1192805-50-7) → 2-methyl-7-methoxy indole (53512-46-2)

Guidance literature:

With potassium hydroxide; In methanol; for 4h; Reflux;

DOI:10.1021/jm301084z

Reference yield: 62.0%

1-(2-nitro-3-methoxyphenyl)-2-nitropropene → 2-methyl-7-methoxy indole (53512-46-2)

Guidance literature:

With acetic acid; palladium-carbon; In ethanol; water; ethyl acetate;

upstream raw materials:

(3-methoxy-2-nitro-phenyl)-acetone

2-[2'-(N-Boc-N-trimethylsilyl-amino)-3'-methoxyphenyl]-1,3-dithiane

3-methoxy 2-nitrobenzaldehyde

1-(3-methoxy-2-nitrophenyl)-2-nitropropanol

Downstream raw materials:

7-methoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept2-yl]-1H-indole-3-carboxamide