Vialinin A

Base Information

Chemical Name:Vialinin A
CAS No.:858134-23-3
Molecular Formula:C34H26O8
Molecular Weight:562.576
Hs Code.:
ChEMBL ID:CHEMBL2012938
DSSTox Substance ID:DTXSID00468621
Metabolomics Workbench ID:101389
Nikkaji Number:J2.207.625F
Pharos Ligand ID:P6V63F7HPDGQ
Wikidata:Q27089142
Mol file:858134-23-3.mol

Synonyms:5',6'-bis(phenylacetoxy)-1,1'-4',1''-terphenyl-2',3',4,4''-tetraol;ganbajunin C;vialinin A

Suppliers and Price of Vialinin A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Vialinin A
1mg
$ 333.00

Usbiological
Vialinin A
1mg
$ 319.00

TRC
VialininA
25mg
$ 1865.00

Cayman Chemical
Vialinin A ≥98%
10mg
$ 385.00

Cayman Chemical
Vialinin A ≥98%
5mg
$ 248.00

Cayman Chemical
Vialinin A ≥98%
1mg
$ 70.00

Cayman Chemical
Vialinin A ≥98%
25mg
$ 805.00

ApexBio Technology
VialininA
25mg
$ 1116.00

ApexBio Technology
VialininA
10mg
$ 510.00

ApexBio Technology
VialininA
5mg
$ 287.00

Total 6 raw suppliers

Chemical Property of Vialinin A

Chemical Property:

Melting Point:220-223 °C
Boiling Point:846.9±65.0 °C(Predicted)
PKA:7.81±0.15(Predicted)
PSA：133.52000
Density:1.370±0.06 g/cm3(Predicted)
LogP:6.13920
Solubility.:Soluble in DMSO
XLogP3:6.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:10
Exact Mass:562.16276778
Heavy Atom Count:42
Complexity:782

Purity/Quality:

97% ^*data from raw suppliers

Vialinin A ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)CC(=O)OC2=C(C(=C(C(=C2C3=CC=C(C=C3)O)O)O)C4=CC=C(C=C4)O)OC(=O)CC5=CC=CC=C5
Uses Vialinin A is a Potent Inhibitor of TNF-α production. Vialinin A is a potent antioxidant.

Technology Process of Vialinin A

There total 19 articles about Vialinin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 956024-15-0
5,6-bis(phenylacetoxy)-4,7-di(p-(t-butyldimethylsilyloxy)phenyl)benzo[d][1,3]dioxol-2-yl acetate

: 858134-23-3
4,5',6',4''-tetrahydroxy-2',3'-di(phenylacetoxy)-[1,1';4',1''-terphenyl]

Guidance literature:: With hydrogenchloride; In dichloromethane; at 20 ℃; for 30h;
DOI:10.1021/ol701590b

Reference yield: 73.0%

: 1377949-05-7
4,7-bis[4-(tert-butyldimethylsilyloxy)phenyl]-2,2-dimethylbenzo[d][1,3]dioxole-5,6-diyl bis(phenylacetate)

: 858134-23-3
4,5',6',4''-tetrahydroxy-2',3'-di(phenylacetoxy)-[1,1';4',1''-terphenyl]

Guidance literature:: With aluminum (III) chloride; ethane-1,2-dithiol; In nitromethane; at -20 ℃; for 0.5h;
DOI:10.1021/jo300565s

Reference yield:

: 956024-09-2
5,6-bis(methoxymethoxy)benzo[d][1,3]dioxole

: 858134-23-3
4,5',6',4''-tetrahydroxy-2',3'-di(phenylacetoxy)-[1,1';4',1''-terphenyl]

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / 0 °C

1.2: isopropyl borate / tetrahydrofuran; hexane / 0.83 h / 0 °C

1.3: 87 percent / AcOH; aq. H₂O₂ / tetrahydrofuran; hexane / 16 h / 0 - 20 °C

2.1: 89 percent / pyridine / 2.5 h / 0 °C

3.1: 96 percent / KBr; K₃PO₄ / (Ph₃P)4Pd / dioxane / 26 h / 100 °C

4.1: 95 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; p-TsOH*H₂O / dioxane / 2.5 h / 50 °C

5.1: sodium dithionite / ethyl acetate; methanol; H₂O / 4 h / 20 °C

6.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

6.2: 88.8 mg / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C

7.1: 90 percent / benzene / 36 h / 80 °C

8.1: 92 percent / methanolic HCl / CH₂Cl₂ / 30 h / 20 °C

With pyridine; hydrogenchloride; potassium phosphate; n-butyllithium; sodium dithionite; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; ethyl acetate; benzene; 3.1: Suzuki coupling;
DOI:10.1021/ol701590b