2-PyrazinecarboxaMide, 3-[(5-chloro-2-fluorobenzoyl)aMino]-

Base Information

• Chemical Name: 2-PyrazinecarboxaMide, 3-[(5-chloro-2-fluorobenzoyl)aMino]-
• CAS No.: 936564-98-6
• Molecular Formula: C₁₂H₈ClFN₄O₂
• Molecular Weight: 294.673
• Mol file: 936564-98-6.mol

Synonyms:2-PyrazinecarboxaMide, 3-[(5-chloro-2-fluorobenzoyl)aMino]-

Chemical Property of 2-PyrazinecarboxaMide, 3-[(5-chloro-2-fluorobenzoyl)aMino]-

Chemical Property:

• PSA: 101.46000
• LogP: 2.70460

Purity/Quality:

≥95% ^*data from raw suppliers

3-(5-Chloro-2-fluorobenzamido)pyrazine-2-carboxamide 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PyrazinecarboxaMide, 3-[(5-chloro-2-fluorobenzoyl)aMino]-

There total 3 articles about 2-PyrazinecarboxaMide, 3-[(5-chloro-2-fluorobenzoyl)aMino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[bis-(5-chloro-2-fluoro-benzoyl)-amino]-pyrazine-2-carboxylic acid ethyl ester (936564-94-2) → 3-(5-chloro-2-fluoro-benzoylamino)-pyrazine-2-carboxylic acid amide (936564-98-6)

Guidance literature:

With ammonia; In ethanol; Heating;

DOI:10.1016/j.bmcl.2007.01.046

Reference yield:

5-chloro-2-fluoro-benzoyl chloride (394-29-6) → 3-(5-chloro-2-fluoro-benzoylamino)-pyrazine-2-carboxylic acid amide (936564-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: ammonia / ethanol / Heating

With pyridine; ammonia; In ethanol;

DOI:10.1016/j.bmcl.2007.01.046

Reference yield:

ethyl 3-amino[2,3-b]pyrazine-2-carboxylate (36526-32-6) → 3-(5-chloro-2-fluoro-benzoylamino)-pyrazine-2-carboxylic acid amide (936564-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: ammonia / ethanol / Heating

With pyridine; ammonia; In ethanol;

DOI:10.1016/j.bmcl.2007.01.046

upstream raw materials:

3-[bis-(5-chloro-2-fluoro-benzoyl)-amino]-pyrazine-2-carboxylic acid ethyl ester

5-chloro-2-fluoro-benzoyl chloride

ethyl 3-amino[2,3-b]pyrazine-2-carboxylate