Histone Acetyltransferase Inhibitor IV, CPTH2

Base Information

Chemical Name:Histone Acetyltransferase Inhibitor IV, CPTH2
CAS No.:357649-93-5
Molecular Formula:C14H14ClN3S
Molecular Weight:291.804
Hs Code.:
Mol file:357649-93-5.mol

Synonyms:Histone Acetyltransferase Inhibitor IV, CPTH2;CPTH2;Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone

Suppliers and Price of Histone Acetyltransferase Inhibitor IV, CPTH2

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
CPTH2
25mg
$ 460.00

TRC
CPTH2
25mg
$ 160.00

Sigma-Aldrich
Histone Acetyltransferase Inhibitor IV, CPTH2
10mg
$ 147.00

Sigma-Aldrich
CPTH2 ≥98% (HPLC), powder
5mg
$ 146.00

Sigma-Aldrich
CPTH2 ≥98% (HPLC), powder
25mg
$ 586.00

ChemScene
CPTH2
1g
$ 850.00

ChemScene
CPTH2
250mg
$ 420.00

ChemScene
CPTH2
100mg
$ 250.00

Axon Medchem
CPTH2 100%
10 mg
$ 137.50

Ambeed
CPTH2 99+%
1g
$ 1083.00

Total 11 raw suppliers

Chemical Property of Histone Acetyltransferase Inhibitor IV, CPTH2

Chemical Property:

Melting Point:190-191 °C
Boiling Point:460.3±37.0 °C(Predicted)
PKA:14.57±0.20(Predicted)
PSA：65.52000
Density:1.38±0.1 g/cm3(Predicted)
LogP:4.87840
Storage Temp.:2-8°C
Sensitive.:Light Sensitive
Solubility.:Soluble in DMSO

Purity/Quality:

99%, ^*data from raw suppliers

CPTH2 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description CPTH2 (357649-93-5) is a selective inhibitor of the histone acetyltransferase Gcn5P both?in vitro?and?in vivo?(IC50?= 0.8 mM).?In vitro, the HAT inhibitory activity of CPTH2 was caused via bridge-interaction with histone H3. It’s?in vivo?activity may involve more histonic and/or non-histonic Gcn5p substrates.
Uses CPTH2 is a histone acetyltransferase inhibitor that modulates Gcn5p dependent functional network in vitro and in vivo. Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in the development of a range of cancers. Consequently, inhibitors of these enzymes have potential as anticancer agents. CPTH2 has been used for the inhibition of histone acetyltransferase in cortical cultures, bud cells and natural killer T cells (iNKT).

Technology Process of Histone Acetyltransferase Inhibitor IV, CPTH2

There total 1 articles about Histone Acetyltransferase Inhibitor IV, CPTH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.97%