2-Hydroxy-5-methoxybenzohydrazide

Base Information

• Chemical Name: 2-Hydroxy-5-methoxybenzohydrazide
• CAS No.: 2905-83-1
• Molecular Formula: C8H10N2O3
• Molecular Weight: 182.179
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID10510004
• Wikidata: Q82367997
• Mol file: 2905-83-1.mol

Synonyms:2-hydroxy-5-methoxybenzohydrazide;2905-83-1;Benzoic acid, 2-hydroxy-5-methoxy-, hydrazide;5-Methoxysalicylhydrazide;2-HYDROXY-5-METHOXYBENZOYLHYDRAZINE;SCHEMBL1639160;DTXSID10510004;MFCD00017054;AKOS003362490;LS-11813;CS-0253783;FT-0694851;EN300-3176535;3-AMINO-3-(10-CHLORO-ANTHRACEN-9-YL)-PROPIONICACID

Chemical Property of 2-Hydroxy-5-methoxybenzohydrazide

Chemical Property:

• PSA: 84.58000
• LogP: 1.09550
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 182.06914219
• Heavy Atom Count: 13
• Complexity: 186

Purity/Quality:

99% ^*data from raw suppliers

2-Hydroxy-5-methoxybenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)O)C(=O)NN

Technology Process of 2-Hydroxy-5-methoxybenzohydrazide

There total 3 articles about 2-Hydroxy-5-methoxybenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-hydroxy-5-methoxybenzoate (22775-40-2) → 2-hydroxy-5-methoxybenzohydrazide (2905-83-1)

Guidance literature:

With hydrazine hydrate; In neat (no solvent); at 120 ℃; Sealed tube;

DOI:10.1016/j.ejmech.2020.112720

Reference yield:

5-methoxysalicylic acid (2612-02-4) → 2-hydroxy-5-methoxybenzohydrazide (2905-83-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 24 h / Reflux

2: hydrazine / 80 - 90 °C

With sulfuric acid; hydrazine;

DOI:10.1039/c8md00328a

Reference yield:

methyl 5-methoxy-2-hydroxybenzoate (2905-82-0) → 2-hydroxy-5-methoxybenzohydrazide (2905-83-1)

Guidance literature:

With hydrazine hydrate;

upstream raw materials:

methyl 5-methoxy-2-hydroxybenzoate

5-methoxysalicylic acid

ethyl 2-hydroxy-5-methoxybenzoate

Downstream raw materials:

4-(2,2-di-p-tolyl-vinyl)-N-(2-hydroxy-5-methoxy-benzoyl)-benzamidrazone