MK2-IN-1 (hydrochloride)

Base Information

• Chemical Name: MK2-IN-1 (hydrochloride)
• CAS No.: 1314118-94-9
• Molecular Formula: C₂₇H₂₅ClN₄O₂*ClH
• Molecular Weight: 509.435
• Mol file: 1314118-94-9.mol

Synonyms:MK2-IN-1 (hydrochloride);MK2 Inhibitor IV

Chemical Property of MK2-IN-1 (hydrochloride)

Chemical Property:

• PSA: 61.61000
• LogP: 6.44740
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility.: insoluble in DMSO; ≥16.5 mg/mL in EtOH with ultrasonic; ≥37.4 mg/mL in H2O

Purity/Quality:

97% ^*data from raw suppliers

MK2-IN-1hydrochloride >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of MK2-IN-1 (hydrochloride)

There total 4 articles about MK2-IN-1 (hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C32H33ClN4O4 (1314119-09-9) → MK2 inhibitor IV (1314118-94-9)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 0.25h;

DOI:10.1021/ml200113y

Reference yield:

5-(4-chlorophenyl)-2-furoic acid (41019-45-8) → MK2 inhibitor IV (1314118-94-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

3: trifluoroacetic acid / 0.25 h / 20 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/ml200113y

Reference yield:

4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine (170911-92-9) → MK2 inhibitor IV (1314118-94-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

3: trifluoroacetic acid / 0.25 h / 20 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/ml200113y

upstream raw materials:

C₃₂H₃₃ClN₄O₄

tert-butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylate

2-(bromomethyl)pyridine hydrobromide

5-(4-chlorophenyl)-2-furoic acid