(2R)-2-(4-bromophenyl)pyrrolidine

Base Information

• Chemical Name: (2R)-2-(4-bromophenyl)pyrrolidine
• CAS No.: 1189155-63-2
• Molecular Formula: C10H12BrN
• Molecular Weight: 226.116
• DSSTox Substance ID: DTXSID10427567
• Nikkaji Number: J2.805.045C
• Wikidata: Q72511317
• Mol file: 1189155-63-2.mol

Synonyms:(2R)-2-(4-bromophenyl)pyrrolidine;1189155-63-2;(R)-2-(4-BROMOPHENYL)PYRROLIDINE;(R)-2-(4-Bromophenyl)-pyrrolidine;SCHEMBL1780308;DTXSID10427567;HIJZBROSVFKSCP-SNVBAGLBSA-N;AM8909;MFCD06762257;AKOS015934478;CS-W000624;AC-31663;AS-37552

Chemical Property of (2R)-2-(4-bromophenyl)pyrrolidine

Chemical Property:

• Boiling Point: 287℃
• Flash Point: 128℃
• PSA: 12.03000
• Density: 1.369
• LogP: 3.20240
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 225.01531
• Heavy Atom Count: 12
• Complexity: 141

Purity/Quality:

99%, ^*data from raw suppliers

(R)-2-(4-Bromophenyl)pyrrolidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(NC1)C2=CC=C(C=C2)Br
• Isomeric SMILES: C1C[C@@H](NC1)C2=CC=C(C=C2)Br

Technology Process of (2R)-2-(4-bromophenyl)pyrrolidine

There total 8 articles about (2R)-2-(4-bromophenyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(R)-1-((S)-2-methyl-propane-2-sulfinyl)-2-(4-bromophenyl)-pyrrolidine (1218989-40-2) → (R)-2-(4-bromophenyl)-pyrrolidine (1189155-63-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jo902710s

Reference yield: 97.0%

(R)-1-((R)-2-methyl-propane-2-sulfinyl)-2-(4-bromophenyl)-pyrrolidine (1207729-74-5) → (R)-2-(4-bromophenyl)-pyrrolidine (1189155-63-2)

Guidance literature:

(R)-1-((R)-2-methyl-propane-2-sulfinyl)-2-(4-bromophenyl)-pyrrolidine; With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 0.5h; Inert atmosphere;

With sodium hydroxide; In water; pH=13;

DOI:10.1039/b917435d

Reference yield: 95.0%

C10H10BrN*H(1+) → (R)-2-(4-bromophenyl)-pyrrolidine (1189155-63-2)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R,R)-f-spiroPhos; hydrogen; In tetrahydrofuran; at 30 ℃; for 10h; under 7600.51 Torr; enantioselective reaction; Autoclave;

DOI:10.1021/acs.orglett.7b01828

upstream raw materials:

(R)-1-((S)-2-methyl-propane-2-sulfinyl)-2-(4-bromophenyl)-pyrrolidine

(R)-1-((R)-2-methyl-propane-2-sulfinyl)-2-(4-bromophenyl)-pyrrolidine

1-(4-bromophenyl)-4-chlorobutan-1-one

C₁₄H₂₁BrClNOS