ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate hydrochloride

Base Information

• Chemical Name: ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate hydrochloride
• CAS No.: 1211510-15-4
• Molecular Formula: C8H14ClNO2
• Molecular Weight: 191.65526
• Hs Code.: 2933990090
• Mol file: 1211510-15-4.mol

Synonyms:ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate hydrochloride;3-Azabicyclo[3.1.0]hexane-6-carboxylic acid ethyl ester hydrochloride

Chemical Property of ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 1.14570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

Ethyl3-Azabicyclo[3.1.0]hexane-6-carboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate hydrochloride

There total 1 articles about ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.15%

3-(tert-butyl) 6-ethyl (1R,5S,6r)-3-azabicyclo[3.1.0]hexane-3,6-dicarboxylate (134575-37-4) → [(1α,5α,6α)-3-aza-bicyclo[3.1.0]hexane]-6-carboxylic acid ethyl ester hydrochloride (1373253-19-0,1211510-15-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 30 ℃; for 2h;

Reference yield:

(1R,5S,6r)-ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate hydrochloric acid (1211510-15-4) → ethyl (1R,5S,6r)-3-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2-methylimidazo[1,2-a]-pyrazin-6-yl)pyrimidin-2-yl]-3-azabicyclo[3.1.0]hexane-6-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / ethanol / 80 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane / 15 h / 100 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; triethylamine; In 1,4-dioxane; ethanol;

Reference yield:

(1R,5S,6r)-ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate hydrochloric acid (1211510-15-4) → (1R,5S,6r)-3-(5-{3-[2-(difluoromethoxy)benzyl]-2-methylimidazo[1,2-a]pyrazin-6-yl}pyrimidin-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / ethanol / 80 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane / 15 h / 100 °C / Inert atmosphere

3: sodium hydroxide; water / tetrahydrofuran / 50 - 80 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol;

upstream raw materials:

3-(tert-butyl) 6-ethyl (1R,5S,6r)-3-azabicyclo[3.1.0]hexane-3,6-dicarboxylate

Refernces