chromazonarol

Base Information

• Chemical Name: chromazonarol
• CAS No.: 57291-88-0
• Molecular Formula: C₂₁H₃₀O₂
• Molecular Weight: 314.468
• Mol file: 57291-88-0.mol

Synonyms:2H-Benzo[a]xanthen-10-ol,1,3,4,4a,5,6,6a,12,12a,12b-decahydro-4,4,6a,12b-tetramethyl-, [4aR-(4aa,6ab,12aa,12bb)]-; (-)-Chromazonarol;Chromazonarol

Chemical Property of chromazonarol

Chemical Property:

• Vapor Pressure: 5.08E-08mmHg at 25°C
• Boiling Point: 430.6°Cat760mmHg
• PKA: 10.45±0.70(Predicted)
• Flash Point: 179.8°C
• PSA: 29.46000
• Density: 1.056g/cm³
• LogP: 5.32840

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of chromazonarol

There total 4 articles about chromazonarol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

8-Epichromazonarol (72937-17-8) → 2-((S)-2,5,5,8a-Tetramethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-benzene-1,4-diol (72853-89-5) + Chromazonarol (57291-88-0)

Guidance literature:

With boron tribromide; In dichloromethane; Yields of byproduct given; 1.) -78 deg C, 30 min, 2.) 25 deg C, 18 h;

DOI:10.1021/jo01296a019

Reference yield:

Triethyl-((4aR,6aS,12aS,12bR)-4,4,6a,12b-tetramethyl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H-benzo[a]xanthen-10-yloxy)-silane → chromazonarol (57291-88-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1021/ja0472026

Reference yield:

(4aR,6aS,12aS,12bR)-10-Methoxy-4,4,6a,12b-tetramethyl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H-benzo[a]xanthene (78856-86-7) → chromazonarol (57291-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: B(C₆F₅)3 / hexane; toluene / 24 h / 20 °C

2: TBAF / tetrahydrofuran / 0.5 h / 0 °C

With tris(pentafluorophenyl)borate; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexane; toluene;

DOI:10.1021/ja0472026

upstream raw materials:

8-Epichromazonarol

(4aR,6aS,12aS,12bR)-10-Methoxy-4,4,6a,12b-tetramethyl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H-benzo[a]xanthene