AKOS AMR10

Base Information

• Chemical Name: AKOS AMR10
• CAS No.: 127285-09-0
• Molecular Formula: C14H22N2
• Molecular Weight: 218.342
• Hs Code.: 2933399090
• Mol file: 127285-09-0.mol

Synonyms:AKOS AMR10;1-[1-(2-PHENYLETHYL)PIPERIDIN-4-YL]METHANAMINE;OTAVA-BB 1083918;UKRORGSYN-BB BBV-105808;1-[1-(2-phenylethyl)piperidin-4-yl]methanamine(SALTDATA: FREE);(1-phenethylpiperidin-4-yl)methanamine

Chemical Property of AKOS AMR10

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 326.647°C at 760 mmHg
• Flash Point: 139.673°C
• PSA: 29.26000
• Density: 0.99g/cm³
• LogP: 2.53800

Purity/Quality:

98%min ^*data from raw suppliers

1-[1-(2-Phenylethyl)piperidin-4-yl]methanamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS AMR10

There total 5 articles about AKOS AMR10 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N-((1-phenethylpiperidin-4-yl)methyl)-1-phenylmethanimine → 1-[1-(2-phenylethyl)-4-piperidinyl]methanamine (127285-09-0)

Guidance literature:

With water; oxalic acid; In dichloromethane; for 3h; Reflux;

DOI:10.3390/ph13080161

Reference yield:

1-phenyl-2-bromoethane (103-63-9) + N-hexahydro-4-pyridinylmethyl-N-phenylmethylidenamine (71207-29-9) → 1-[1-(2-phenylethyl)-4-piperidinyl]methanamine (127285-09-0)

Guidance literature:

1-phenyl-2-bromoethane; N-hexahydro-4-pyridinylmethyl-N-phenylmethylidenamine; With potassium carbonate; In ethanol; for 24h; Heating / reflux;

With hydrogenchloride; In water; at 20 ℃; for 2h;

With sodium hydroxide; In water; pH=~ 13;

Reference yield:

4-Aminomethylpiperidine (7144-05-0) → 1-[1-(2-phenylethyl)-4-piperidinyl]methanamine (127285-09-0)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 3 h / 25 °C

2: potassium carbonate / ethanol / 24 h / Reflux

3: water; hydrogenchloride / 2 h / 25 °C

With hydrogenchloride; water; potassium carbonate; In ethanol; toluene;

DOI:10.1002/cmdc.201800199

upstream raw materials:

1-phenyl-2-bromoethane

N-hexahydro-4-pyridinylmethyl-N-phenylmethylidenamine

4-Aminomethylpiperidine

Downstream raw materials:

2-methyl-N-((1-(2-phenylethyl)piperidin-4-yl)methyl)-2H-indazole-3-carboxamide

2-methyl-N-{[1-(2-phenylethyl)piperidin-4-yl]methyl}-2H-indazol-3-carboxamide hydrochloride

1-isopentyl-N-[[1-(2-phenylethyl)-4-piperidinyl]methyl]-1H-indazole-3-carboxamide

1-sec-butyl-N-[[1-(2-phenylethyl)-4-piperidinyl]methyl]-1H-indazole-3-carboxamide

Refernces

• 1、 Furlotti, Guido,Alisi, Maria Alessandra,Cazzolla, Nicola,Ceccacci, Francesca,Garrone, Beatrice,Gasperi, Tecla,La Bella, Angela,Leonelli, Francesca,Loreto, Maria Antonietta,Magarò, Gabriele,Mangano, Giorgina,Bettolo, Rinaldo Marini,Masini, Emanuela,Miceli, Martina,Migneco, Luisa Maria,Vitiello, Marco. "Targeting Serotonin 2A and Adrenergic α1 Receptors for Ocular Antihypertensive Agents: Discovery of 3,4-Dihydropyrazino[1,2-b]indazol-1(2H)-one Derivatives". . p. 1597 - 1607. Retrieved 2018/07/30.
• 2、 -. "(N-phthalimidoalkyl) piperidines useful as treatments for psychosis". . . Retrieved 2008/06/13.