Propan-2-yl 11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oate

Base Information

• Chemical Name: Propan-2-yl 11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oate
• CAS No.: 71845-66-4
• Molecular Formula: C23H38O5
• Molecular Weight: 394.54
• DSSTox Substance ID: DTXSID10693987
• Mol file: 71845-66-4.mol

Synonyms:DTXSID10693987;Propan-2-yl 11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oate

Chemical Property of Propan-2-yl 11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oate

Chemical Property:

• PSA: 83.83000
• LogP: 4.11810
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 14
• Exact Mass: 394.27192431
• Heavy Atom Count: 28
• Complexity: 523

Purity/Quality:

99% ^*data from raw suppliers

Prostaglandin E2 isopropyl ester ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)OC(C)C)O)O
• Description: Prostaglandin E2 (PGE2) isopropyl ester is a more lipophilic form of the free acid, PGE2. PG esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid by endogenous esterases upon in vivo administration, making the esters useful prodrugs. In general, the C-1 esters of PGs show greatly diminished receptor activity in vitro compared to the parent free acids.

Technology Process of Propan-2-yl 11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oate

There total 1 articles about Propan-2-yl 11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Dinoproston-isopropylester (71845-66-4,330589-21-4)

Guidance literature:

Aus Dinoproston (II), Isopropylbromid, N,N-Diisopropyl-ethylamin;

DOI:10.1002/jps.2600680711