Technology Process of L-Proline, N-[(1,1-diMethylethoxy)carbonyl]-3-[[(phenylMethoxy)carbonyl]aMino]-L-alanyl-5-(2-propen-1-yl)-, Methyl ester
There total 9 articles about L-Proline, N-[(1,1-diMethylethoxy)carbonyl]-3-[[(phenylMethoxy)carbonyl]aMino]-L-alanyl-5-(2-propen-1-yl)-, Methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2S)-5-allyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester;
With
hydrogenchloride;
In
1,4-dioxane; methanol;
at 20 ℃;
3-{[(benzyloxy)carbonyl]amino}-N-(tert-butoxycarbonyl)-L-alanine;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
- Guidance literature:
-
(2S)-5-allyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester;
With
hydrogenchloride;
In
1,4-dioxane; methanol;
at 20 ℃;
Nα-Boc,Nβ-Z-Dap*DCHA;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: boron trifluoride diethyl etherate / diethyl ether / -78 °C
2: hydrogenchloride / acetonitrile; 1,4-dioxane
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane
With
hydrogenchloride; boron trifluoride diethyl etherate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1358/dof.2017.042.12.2702829