7-AMINO-4-METHYL-3-COUMARINYLACETIC ACID

Base Information

Chemical Name:7-AMINO-4-METHYL-3-COUMARINYLACETIC ACID
CAS No.:106562-32-7
Molecular Formula:C12H11 N O4
Molecular Weight:233.224
Hs Code.:29322090
Mol file:106562-32-7.mol

Synonyms:7-Amino-4-methylcoumarin-3-aceticacid; AMCA; AMCA (coumarin); AMCA blue

Suppliers and Price of 7-AMINO-4-METHYL-3-COUMARINYLACETIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
7-Amino-4-methyl-3-coumarinylacetic acid
100mg
$ 1260.00

TCI Chemical
7-Amino-4-methylcoumarin-3-acetic Acid >95.0%(T)
250mg
$ 133.00

TCI Chemical
7-Amino-4-methylcoumarin-3-acetic Acid >95.0%(T)
50mg
$ 41.00

Sigma-Aldrich
7-Amino-4-methyl-3-coumarinylacetic acid BioReagent, suitable for fluorescence, ~90% (HPLC)
100mg
$ 79.50

Sigma-Aldrich
7-Amino-4-methyl-3-coumarinylacetic acid BioReagent, suitable for fluorescence, ~90% (HPLC)
500mg
$ 286.00

Crysdot
2-(7-Amino-4-methyl-2-oxo-2H-chromen-3-yl)aceticacid 95+%
250mg
$ 184.00

Crysdot
2-(7-Amino-4-methyl-2-oxo-2H-chromen-3-yl)aceticacid 95+%
1g
$ 460.00

Chem-Impex
7-Amino-4-methylcoumarin-3-aceticacid,≥95%(Assaybytitration) ≥95%(Assaybytitration)
250MG
$ 150.22

Chemenu
2-(7-Amino-4-methyl-2-oxo-2H-chromen-3-yl)aceticacid 95%
1g
$ 430.00

Cayman Chemical
7-Amino-4-methyl-3-coumarinylacetic Acid
50mg
$ 38.00

Total 31 raw suppliers

Chemical Property of 7-AMINO-4-METHYL-3-COUMARINYLACETIC ACID

Chemical Property:

Vapor Pressure:2.58E-11mmHg at 25°C
Boiling Point:512.2°Cat760mmHg
PKA:3.80±0.10(Predicted)
Flash Point:263.6°C
PSA：93.53000
Density:1.391g/cm³
LogP:1.89190
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Solubility.:DMF: soluble

Purity/Quality:

99%, ^*data from raw suppliers

7-Amino-4-methyl-3-coumarinylacetic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Description AMCA is fluorescent protein labeling agent. It contains an N-hydroxysuccinimide ester that reacts with lysine residues to form photostable amide links. Upon activation with UV light, AMCA displays emission maxima of 400-460 nm. It has commonly been used in multiplex immunophenotyping applications.
Uses 7-AMINO-4-METHYL-3-COUMARINYLACETIC ACID is a blue fluorescent dye. Its desirable properties include a relatively large Stoke's shift and resistance to photobleaching. 7-AMINO-4-METHYL-3-COUMARINYLACETIC ACID is used as contrasting probes for double and triple labeling in im Non-Activated, Amine-Reactive, fluorescent probe

Technology Process of 7-AMINO-4-METHYL-3-COUMARINYLACETIC ACID

There total 6 articles about 7-AMINO-4-METHYL-3-COUMARINYLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 113721-84-9
7-carboethoxyamido-4-methylcoumarin-3-acetic acid ethyl ester

: 106562-32-7
2-(7-amino-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid

Guidance literature:: With sodium hydroxide; In water; for 16h; Reflux;
DOI:10.1002/anie.201811391

Reference yield:

: 591-27-5
m-Hydroxyaniline

: 106562-32-7
2-(7-amino-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / ethyl acetate / Heating

2: 2.) 75percent aq. H₂SO₄ / 2.) 25 deg C

3: 1.) KOH, 2.) H₂SO₄, AcOH / 1.) MeOH, reflux, 2.) reflux

With potassium hydroxide; sulfuric acid; acetic acid; In ethyl acetate;
DOI:10.1016/S0960-894X(98)00130-9

Reference yield:

: 7159-96-8
ethyl N-(3-hydroxyphenyl)carbamate

: 106562-32-7
2-(7-amino-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) 75percent aq. H₂SO₄ / 2.) 25 deg C

2: 1.) KOH, 2.) H₂SO₄, AcOH / 1.) MeOH, reflux, 2.) reflux

With potassium hydroxide; sulfuric acid; acetic acid;
DOI:10.1016/S0960-894X(98)00130-9