2-(7-Octyn-1-yl)-1H-isoindole-1,3-dione

Base Information

• Chemical Name: 2-(7-Octyn-1-yl)-1H-isoindole-1,3-dione
• CAS No.: 17170-26-2
• Molecular Formula: C₁₆H₁₇NO₂
• Molecular Weight: 255.316
• Hs Code.: 2925190090
• Mol file: 17170-26-2.mol

Synonyms:2-(7-Octyn-1-yl)-1H-isoindole-1,3-dione

Chemical Property of 2-(7-Octyn-1-yl)-1H-isoindole-1,3-dione

Chemical Property:

• Boiling Point: 386.7±25.0 °C(Predicted)
• PKA: -2.12±0.20(Predicted)
• PSA: 37.38000
• Density: 1.145±0.06 g/cm3(Predicted)
• LogP: 2.80420

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(7-Octyn-1-yl)-1H-isoindole-1,3-dione 96% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn,N
• Statements: 22-50

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(7-Octyn-1-yl)-1H-isoindole-1,3-dione

There total 2 articles about 2-(7-Octyn-1-yl)-1H-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

8-bromooct-1-yne (81216-13-9) + potassium phtalimide (1074-82-4) → 2-(hept-6-yn-1-yl)isoindoline-1,3-dione (17170-26-2)

Guidance literature:

In N,N-dimethyl-formamide; at 70 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol801390h DOI:10.1021/jo101234u

Reference yield: 99.0%

oct-7-yn-1-ol (871-91-0) → 2-(hept-6-yn-1-yl)isoindoline-1,3-dione (17170-26-2)

Guidance literature:

With di-isopropyl azodicarboxylate; potassium phtalimide; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 20h;

Reference yield: 76.0%

2-(hept-6-yn-1-yl)isoindoline-1,3-dione (17170-26-2) → 8-aminooct-1-yne (14502-43-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 4h; Reflux; Inert atmosphere;

DOI:10.1021/ol801390h

upstream raw materials:

8-bromooct-1-yne

potassium phtalimide

oct-7-yn-1-ol

Downstream raw materials:

8-aminooct-1-yne

Refernces

• 1、 Romuald, Camille,Busseron, Eric,Coutrot, Frederic. "Very contracted to extended co -conformations with or without oscillations in two- and three-station ['2]daisy chains". supporting information; experimental part. p. 6516 - 6531. Retrieved 2010/12/24.